SUMOylation in Human Pathogenic Fungi: Role in Physiology and Virulence

Journal of Fungi
Mahima Sagar SahuRupinder Kaur

Abstract

The small ubiquitin-related modifier (SUMO) protein is an important component of the post-translational protein modification systems in eukaryotic cells. It is known to modify hundreds of proteins involved in diverse cellular processes, ranging from nuclear pore dynamics to signal transduction pathways. Owing to its reversible nature, the SUMO-conjugation of proteins (SUMOylation) holds a prominent place among mechanisms that regulate the functions of a wide array of cellular proteins. The dysfunctional SUMOylation system has been associated with many human diseases, including neurodegenerative and autoimmune disorders. Furthermore, the non-pathogenic yeast Saccharomyces cerevisiae has served as an excellent model to advance our understanding of enzymes involved in SUMOylation and proteins modified by SUMOylation. Taking advantage of the tools and knowledge obtained from the S. cerevisiae SUMOylation system, research on fungal SUMOylation is beginning to gather pace, and new insights into the role of SUMOylation in the pathobiology of medically important fungi are emerging. Here, we summarize the known information on components of the SUMOylation machinery, and consequences of overexpression or deletion of these components in t...Continue Reading

References

Jul 28, 1995·The Journal of Biological Chemistry·R J DohmenA Varshavsky
Jan 1, 1995·Respiration; International Review of Thoracic Diseases·M von EiffJ van de Loo
Oct 27, 1997·The Journal of Biological Chemistry·E S Johnson, G Blobel
Mar 27, 1999·Nature·S J Li, M Hochstrasser
Jun 12, 1999·Biochemical and Biophysical Research Communications·Y TakahashiY Kikuchi
Dec 1, 1999·The Journal of Cell Biology·E S Johnson, G Blobel
Mar 14, 2000·Molecular and Cellular Biology·S J Li, M Hochstrasser
Jul 14, 2001·The Journal of Biological Chemistry·M H TathamR T Hay
Oct 2, 2002·The Journal of Biological Chemistry·Kalman P BencsathBrenda A Schulman
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David T FiskPowel H Kazanjian
Aug 28, 2003·The Journal of Biological Chemistry·Gwendolyn R BylebylErica S Johnson
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ted JonesStewart Scherer
Jun 11, 2004·Annual Review of Biochemistry·Erica S Johnson
Jul 2, 2004·Nature·Bernard DujonJean-Luc Souciet
Jul 28, 2004·The Journal of Biological Chemistry·Stephen W Martin, James B Konopka
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Aug 25, 2004·The Journal of Biological Chemistry·James A WohlschlegelJohn R Yates
Sep 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jing SongYuan Chen
Dec 2, 2004·Biochimica Et Biophysica Acta·Cecile M Pickart, Michael J Eddins
Dec 14, 2004·The Journal of Biological Chemistry·J Thomas HannichMark Hochstrasser
Jan 18, 2005·Clinical Microbiology Reviews·Judith A Woodfolk
Mar 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiaolan Zhao, Günter Blobel
Apr 6, 2005·Molecular Cell·Ronald T Hay
Jul 6, 2005·Current Opinion in Microbiology·Rupinder KaurBrendan P Cormack
Jun 20, 2006·Molecular and Cellular Biology·Robert C A M van WaardenburgMary-Ann Bjornsti
Nov 2, 2006·Journal of Cell Science·Alison ReindleErica S Johnson
Apr 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rupinder KaurBrendan P Cormack
May 15, 2007·Trends in Biochemical Sciences·Debaditya Mukhopadhyay, Mary Dasso
Oct 6, 2007·Biological & Pharmaceutical Bulletin·Li HuapingLiu Yuhuan
Nov 15, 2007·Nature Reviews. Molecular Cell Biology·Ruth Geiss-Friedlander, Frauke Melchior
Jan 26, 2008·Cell Division·Mary Dasso
Feb 12, 2008·Fungal Genetics and Biology : FG & B·Koon Ho WongMeryl A Davis
Feb 20, 2008·Expert Review of Proteomics·Van G Wilson, Phillip R Heaton
Mar 4, 2008·Trends in Cell Biology·Benoît Palancade, Valérie Doye
Nov 4, 2008·Applied and Environmental Microbiology·Edyta SzewczykBerl R Oakley
May 28, 2009·Science Signaling·Filip GolebiowskiRonald T Hay
Jul 15, 2009·Clinical Microbiology Reviews·Taylor R T Dagenais, Nancy P Keller

❮ Previous
Next ❯

Citations

Dec 10, 2020·Computational and Structural Biotechnology Journal·Dipika GuptaKrishnaveni Mishra
Jul 25, 2021·International Journal of Molecular Sciences·Manuel Sánchez López-BergesHubertus Haas

❮ Previous
Next ❯

Methods Mentioned

BETA
Ubiquitination
thermal stress

Software Mentioned

BLASTP

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Related Papers

Seikagaku. The Journal of Japanese Biochemical Society
Yoshiko Kikuchi
© 2021 Meta ULC. All rights reserved