SUMOylation of Blimp-1 is critical for plasma cell differentiation.

EMBO Reports
Hsia-Yuan YingKuo-I Lin

Abstract

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression--correlating with a reduced interaction with a histone deacetylase, HDAC2--and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

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Citations

Jun 13, 2015·Clinical Reviews in Allergy & Immunology·Yan Bao, Xuetao Cao
Jul 28, 2018·European Journal of Immunology·Natasja A M KragtenKlaas P J M van Gisbergen
May 7, 2020·International Journal of Molecular Sciences·Chao-Yuan HsuHuey-Kang Sytwu
Jan 9, 2020·Molecular Cancer·Pan WangJing Liu
Jul 30, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Kai ChiuKuo-I Lin
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Sajeev T KRam Kumar Mishra

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