SUMOylation of synaptic and synapse-associated proteins: An update.

Journal of Neurochemistry
Jeremy M HenleyKevin A Wilkinson

Abstract

SUMOylation is a post-translational modification that regulates protein signalling and complex formation by adjusting the conformation or protein-protein interactions of the substrate protein. There is a compelling and rapidly expanding body of evidence that, in addition to SUMOylation of nuclear proteins, SUMOylation of extranuclear proteins contributes to the control of neuronal development, neuronal stress responses and synaptic transmission and plasticity. In this brief review we provide an update of recent developments in the identification of synaptic and synapse-associated SUMO target proteins and discuss the cell biological and functional implications of these discoveries.

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Citations

Oct 30, 2020·Brain Sciences·Luca ColnaghiMario Salmona
Aug 31, 2021·European Journal of Histochemistry : EJH·Andrea ConzLuca Colnaghi
Dec 11, 2021·Frontiers in Molecular Neuroscience·Marie PronotCarole Gwizdek
Jul 3, 2021·Current Alzheimer Research·Xiaokang GongXiji Shu

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