Sunburn cell formation, dendritic cell migration, and immunomodulatory factor production after solar-simulated irradiation of sunscreen-treated human skin explants in vitro

The Journal of Investigative Dermatology
Rainer Hofmann-WellenhofPeter Wolf

Abstract

Using human skin explants, we investigated the effects of two different sunscreen preparations containing a chemical UVB filter alone [sun protection factor (SPF) 5.2] or UVA+UVB filter [SPF 6.2] on sunburn cell formation, dendritic cell (DC) migration, CD86- and CD1a-positive cell number, and tumor necrosis factor alpha (TNFalpha) and interleukin (IL)-1, IL-10, and IL-12 production in the skin after irradiation with different doses of solar-simulated UV radiation. Sunscreen- or placebo-treated skin explants were irradiated with solar-simulated UV radiation at 0.5, 1, and 2 minimal erythematous dose equivalents (MEDE) (as determined in an in vivo human study) multiplied by the SPF of the placebo or sunscreens. After irradiation, skin explants were floated on RMPI medium for 48 h. Cells that had emigrated and the skin explants were histologically analyzed, and the soluble mediators were measured in the supernatants by ELISA. Exposure to UV radiation led to concentration-dependent increases in sunburn cell formation and TNFalpha production but a concentration-dependent decrease in DC migration and CD86- and CD1a-positive cell number in the epidermis. Both chemical sunscreens protected against those alterations. The immunoprotecti...Continue Reading

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Citations

Mar 17, 2007·The Journal of Investigative Dermatology·Jürgen BaierWolfgang Bäumler
Feb 14, 2006·The Journal of Investigative Dermatology·Sébastien CorreMarie-Dominique Galibert
Mar 1, 2011·The Journal of Dermatology·Jürgen ScheeleFaiz Niazi
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Apr 20, 2006·Progress in Biophysics and Molecular Biology·R M Tyrrell, V E Reeve
Oct 30, 2014·Acta Cirúrgica Brasileira·Silvana Aparecida Alves Corrêa de NoronhaAlfredo Gragnani
Nov 5, 2010·Journal of Clinical Microbiology·Jianli DaiJudith A Johnson

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