PMID: 11329390May 1, 2001Paper

Sundowning and circadian rhythms in Alzheimer's disease

The American Journal of Psychiatry
L VolicerA Satlin

Abstract

The goal of this study was to determine changes of circadian rhythms induced by Alzheimer's disease and to explore relationships among rhythm disturbances, sundowning, and sleep disturbances in patients with Alzheimer's disease. "Sundowning" is the occurrence or exacerbation of behavioral symptoms of Alzheimer's disease in the afternoon and evening. Circadian rhythms of core body temperature and motor activity were measured in 25 patients with diagnoses of probable Alzheimer's disease and in nine healthy individuals. The subjects with Alzheimer's disease were divided according to the occurrence of sundowning as determined by staff reports. The subjects with Alzheimer's disease had less diurnal motor activity, a higher percentage of nocturnal activity, lower interdaily stability of motor activity, and a later activity acrophase (time of peak) than did the healthy individuals. They also had a higher mesor (fitted mean) temperature, higher amplitude of the fitted cosine temperature curve, and later temperature acrophase than did the healthy subjects. The severity of sundowning was associated with later acrophase of temperature, less correlation of circadian temperature rhythm with a 24-hour cycle, and lower amplitude of temperatur...Continue Reading

Citations

Mar 8, 2006·Psychopharmacology·Sebastian WaltherDieter Kunz
Jun 15, 2007·Zeitschrift für Gerontologie und Geriatrie·R Mahlberg, S Walther
Feb 9, 2012·Current Neurology and Neuroscience Reports·Qiuping Pearl ZhouKathy C Richards
Apr 3, 2003·Current Treatment Options in Neurology·Susan M. McCurry, Sonia Ancoli-Israel
Jun 16, 2005·Trends in Biotechnology·Ana Otero, Ken Goto
Jan 25, 2003·Experimental Gerontology·Debra J Skene, Dick F Swaab
Jan 22, 2003·The Plant Journal : for Cell and Molecular Biology·Dorothee StaigerLuca Eckstein
Jan 25, 2003·The European Journal of Neuroscience·Debby Van DamPeter P De Deyn
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tracy A BedrosianRandy J Nelson
Dec 3, 2011·Traffic Injury Prevention·Catherine Hackett RennerJames R Swegle
Mar 29, 2008·Brain : a Journal of Neurology·David G HarperAndrew Satlin
Oct 7, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ladislav Volicer, Ann C Hurley
Jul 8, 2011·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Jyoti SavlaFrank Gwazdauskas
Mar 3, 2011·Journal of Clinical Psychopharmacology·Sebastian WaltherWerner Strik
Feb 15, 2013·The Journal of Nervous and Mental Disease·José María García-AlbercaMiguel Ángel Barbancho
Nov 18, 2011·Alzheimer Disease and Associated Disorders·Daniel A LlanoRobert A Lenz
Jan 21, 2012·Alzheimer Disease and Associated Disorders·Jennifer MerrileesBruce L Miller
Jan 18, 2006·Annual Review of Medicine·David Bachman, Peter Rabins
May 11, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Navita KaushalDavid Gozal
Aug 7, 2012·Disease Models & Mechanisms·Elysse M KnightCatherine B Lawrence
Jun 3, 2008·PLoS Genetics·Alun R Barnard, Patrick M Nolan
Oct 12, 2012·PloS One·Deborah R BooneHelen L Hellmich
Dec 7, 2013·International Journal of Environmental Research and Public Health·Suzanne MartinMaurice Mulvenna
Sep 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Salvador Huitron-ResendizHoward S Fox
Mar 22, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Jeannette Y Wick, Guido R Zanni
Mar 21, 2009·The Journal of Nutrition, Health & Aging·V CochenB Vellas
Dec 5, 2012·The Journal of Nutrition, Health & Aging·L VolicerE G Stopa
May 4, 2012·Neuromolecular Medicine·Sarah M Rothman, Mark P Mattson
Jul 27, 2010·Chronobiology International·Michael R Gorman, Steven Yellon
Dec 5, 2014·Chronobiology International·Pablo Jesús López-SotoMaría Aurora Rodríguez-Borrego
Oct 28, 2015·Annals of Neurology·Chiara La MorgiaValerio Carelli
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Raymond L OwnbySteven Sevush
Jan 1, 2013·Biological Psychiatry·Andrew N CooganJohannes Thome
Dec 19, 2012·Behavioural Brain Research·Ann Van der JeugdRudi D'Hooge
May 26, 2012·Experimental Neurology·Tracy A Bedrosian, Randy J Nelson
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Daniel Carneiro CarrettieroMaria Camila Almeida
Jun 24, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·A KuhlmeiT Nikolaus
Aug 10, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Asim Sattwa MandalKetousetuo Kuotsu
Jun 15, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ing-Jy TsengChaur-Jong Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.