Sunitinib in Patients With Metastatic Renal Cell Carcinoma: Clinical Outcome According to International Metastatic Renal Cell Carcinoma Database Consortium Risk Group

Clinical Genitourinary Cancer
Brian I RiniRobert J Motzer

Abstract

Sunitinib malate, a targeted tyrosine kinase inhibitor, is standard of care for metastatic renal cell carcinoma (mRCC) and serves as the active comparator in several ongoing mRCC clinical trials. In this analysis we report benchmarks for clinical outcomes on the basis of International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk groups for patients treated with sunitinib for mRCC in a first-line setting. A retrospective analysis was performed on data from sunitinib-treated patients (n = 375) in the pivotal phase III trial of sunitinib versus interferon-α as first-line treatment for mRCC. Objective response rates (ORRs) were determined from independently reviewed radiologic assessments. The Kaplan-Meier method was used to estimate median progression-free survival (PFS) and median overall survival (OS) according to patient risk group. Median PFS (95% confidence interval [CI]) was 14.1 (13.4-17.1), 10.7 (10.5-12.5), 2.4 (1.1-4.7), and 10.6 (8.1-10.9) months in sunitinib-treated patients in the IMDC favorable (n = 134), intermediate (n = 205), poor (n = 34), and intermediate + poor (n = 239) risk groups, respectively. Median OS (95% CI) was 23.0 (19.8-27.8), 5.1 (4.3-9.9), and 20.3 (16.8-23.0) months in sunitinib...Continue Reading

Citations

Nov 26, 2019·Asia-Pacific Journal of Clinical Oncology·Andrew SchmidtLaurence Krieger
Sep 8, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Toshikazu TanakaChikara Ohyama
Sep 15, 2020·Journal of Biochemical and Molecular Toxicology·Shan XuPengsheng Zheng
Feb 18, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S Vázquez EstévezL M Anton Aparicio
Sep 16, 2020·Expert Review of Anticancer Therapy·Ehab AbdouEnrique Grande
Jun 12, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maddalena CentanniLena E Friberg
Feb 25, 2020·Translational Oncology·Paweł SobczukAnna M Czarnecka
Jun 24, 2019·Clinical Genitourinary Cancer·Annelies VerbiestBenoit Beuselinck
Jul 1, 2021·International Journal of Clinical Oncology·Sei NaitoNorihiko Tsuchiya

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