Sunlight exposure and pathogenesis of uveal melanoma

Survey of Ophthalmology
Arun D SinghJohn McKenzie

Abstract

Uveal melanoma is the most frequent primary malignant intraocular tumor of adults. Among various non-modifiable risk factors, Caucasian race seems to be the most significant with light skin color, blond hair, and blue eyes being specific risk factors. The racial predisposition to uveal melanoma have been explained on the basis of susceptibility of Caucasian race to oncogenic effects of sunlight. Although there is ample evidence in support of this hypothesis in regard to skin melanoma, the evidence in regard to uveal melanoma is insufficient and contradictory. In the following review, we examine physiologic, epidemiological, and genetic data in order to determine the role of sunlight exposure in the pathogenesis of uveal melanoma.

References

Dec 15, 1992·Cancer·U A AjaniE S Gragoudas
Sep 1, 1990·Archives of Ophthalmology·J M SeddonP H Blitzer
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S E FreemanB M Sutherland
Oct 1, 1989·The British Journal of Ophthalmology·A G CasswellJ L Hungerford
Mar 1, 1989·Archives of Ophthalmology·M W JohnsonJ R Wolter
Feb 15, 1988·International Journal of Cancer. Journal International Du Cancer·S M Schwartz, N S Weiss
Jan 1, 1988·Survey of Ophthalmology·K M EganD M Albert
Jan 1, 1988·American Journal of Public Health·F S RosenthalH R Taylor
Oct 1, 1986·American Journal of Public Health·F S RosenthalH R Taylor
Dec 1, 1985·Klinische Monatsblätter für Augenheilkunde·P K LommatzschH Bernt
Sep 26, 1985·The New England Journal of Medicine·M A TuckerJ F Fraumeni
Oct 15, 1985·American Journal of Ophthalmology·G H KlimanJ A Shields
Jul 1, 1973·American Journal of Ophthalmology·J P Ganley, G W Comstock
Jul 1, 1968·American Journal of Ophthalmology·W J Geeraets, E R Berry
Mar 1, 1984·Survey of Ophthalmology·G A PeymanR C Zeimer
Nov 1, 1984·American Journal of Ophthalmology·J Rootman, R P Gallagher
Sep 30, 1983·Documenta Ophthalmologica. Advances in Ophthalmology·S Zigman
Jan 1, 1982·International Ophthalmology Clinics·P K KuoB F Wu
May 4, 1995·International Journal of Cancer. Journal International Du Cancer·J IscovichR Steinitz
Jan 1, 1993·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·M AoyagiO Matsubara
May 1, 1993·Journal of the American Academy of Dermatology·H IhnY Ishibashi
Apr 1, 1996·Archives of Ophthalmology·C L WilkersonD M Albert
Feb 1, 1996·American Journal of Ophthalmology·S Panda-JonasM Jakobczyk-Zmija
Jan 1, 1996·Epidemiology·E A HollyA H Smith
Jan 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C ReméF Hafezi
Mar 1, 1994·Ophthalmic Epidemiology·P J DolinJ L Hungerford
Jan 1, 1997·American Industrial Hygiene Association Journal·T D Tenkate, M J Collins
Feb 1, 1997·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·O KocabalkanY Güngen
Jul 17, 1997·International Journal of Cancer. Journal International Du Cancer·J L BulliardJ M Elwood
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·J M Elwood, J Jopson
Feb 6, 1998·The International Journal of Biochemistry & Cell Biology·P A Riley
May 14, 1998·The Journal of Investigative Dermatology·N KobayashiT Mori
Jun 17, 1998·Ophthalmology·C E MargoK Billiris
Apr 29, 1999·The New England Journal of Medicine·B A GilchrestM Yaar
May 10, 2000·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·S Zigman
Jan 3, 2001·The British Journal of Ophthalmology·K MichalovaR A Allardyce
Apr 20, 2001·Journal of the American Academy of Dermatology·S Q WangR S Bart
Mar 12, 2002·The Journal of Investigative Dermatology·A DemunterJ J van den Oord
Mar 20, 2002·Nature Reviews. Cancer·E C Friedberg
Apr 23, 2002·The British Journal of Dermatology·Jean-Paul Ortonne

❮ Previous
Next ❯

Citations

May 28, 2013·ISRN Dermatology·Fabrizio AyalaPaolo A Ascierto
Dec 3, 2014·Journal of Photochemistry and Photobiology. B, Biology·Guang-Cong LiuYang Liu
Nov 19, 2010·The New England Journal of Medicine·Catherine D Van RaamsdonkBoris C Bastian
Mar 7, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Carolina Belmar-LopezPilar Martin-Duque
Dec 8, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I Franco-LieM Abdelnoor
Oct 15, 2013·Current Oncology Reports·Sapna P Patel
Apr 15, 2006·Expert Review of Anticancer Therapy·Bertil Damato
Oct 26, 2013·Archivos de la Sociedad Española de Oftalmología·N VicenteF López-Lara
May 24, 2011·Progress in Retinal and Eye Research·F Behar-CohenD Attia
Mar 30, 2010·American Journal of Ophthalmology·Martin A Mainster, Patricia L Turner
Nov 4, 2009·Survey of Ophthalmology·Martin A Mainster, Patricia L Turner
Jul 21, 2011·Journal of Skin Cancer·Vasilios P Papastefanou, Victoria M L Cohen
Dec 12, 2012·Pathology·Klaus G Griewank, Rajmohan Murali
Aug 19, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P NathanN Turnbull
Jan 5, 2006·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Michel MillodotJacob Pe'er
Mar 19, 2008·Photochemistry and Photobiology·Dan-Ning HuTadeusz Sarna
Oct 21, 2010·Genes, Chromosomes & Cancer·Leslie HohKaren Sisley
Mar 26, 2013·The British Journal of Dermatology·J OláhZ Csoma
Dec 12, 2013·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Ariela Gordon-ShaagEinat Shneor
Aug 29, 2013·Photochemistry and Photobiology·Justin D MalletPatrick J Rochette
Aug 1, 2006·Optometry : Journal of the American Optometric Association·Elizabeth Hoppe, Richard Frankel
Sep 13, 2005·Ophthalmology·Arun D SinghAllan Topham
Jun 16, 2015·Journal of Ophthalmology·Patrick LoganMiguel N Burnier
Apr 2, 2015·Indian Journal of Ophthalmology·Pukhraj RishiCarol L Shields
Jan 18, 2017·Veterinary Ophthalmology·Todd L MarloLeandro B C Teixeira
May 11, 2007·Veterinary Pathology·M K ZarfossR R Dubielzig
Nov 23, 2006·Melanoma Research·Jean-Claude A MarshallMiguel N Burnier
Aug 23, 2006·Photochemistry and Photobiology·Guo-Pei YuSteven A McCormick
Apr 9, 2009·Journal of Experimental & Clinical Cancer Research : CR·Sebastian Di CesareMiguel N Burnier
Jul 7, 2007·Journal of Biomedical Optics·Gladimir V G Baranoski, Michael W Y Lam
Feb 23, 2010·Melanoma Research·Helena PópuloJosé Manuel Lopes
Nov 18, 2005·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·William H Tolleson
Jun 27, 2013·British Journal of Cancer·K G GriewankM Zeschnigk
Apr 30, 2016·Seminars in Ophthalmology·Erin E NicholsAnthony B Daniels
Apr 11, 2020·Nature Reviews. Disease Primers·Martine J JagerBertil E Damato
Dec 15, 2005·Seminars in Ophthalmology·Peter G Hovland, Clement Trempe
Jul 19, 2013·Cancer Discovery·Simon J FurneyRichard Marais
Jun 26, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gary G Schwartz
Mar 20, 2021·Acta Ophthalmologica·Isabel Smidt-NielsenJens Folke Kiilgaard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Claire M VajdicBruce K Armstrong
Ophthalmology Clinics of North America
Arun D SinghStefan Seregard
© 2022 Meta ULC. All rights reserved