Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results

Photodermatology, Photoimmunology & Photomedicine
A FourtanierS Seité

Abstract

UVA exposure of human skin mainly produces reactive oxygen species (ROS) leading to DNA, cell and tissue damage. It alters immune function, pigmentation and it is certainly responsible for a large part of photoaging changes. Moreover UVA is implicated in the etiology of several photodermatoses. As a consequence, to provide adequate protection, sunscreens or skin care products for daily use protective products need UVA absorbers combined with UVB ones. To assess the efficacy of sunscreens containing a broad-spectrum UVA absorber the Mexoryls SX or ecamsule and to compare formulations with and without it through a large number of clinical studies in human volunteers and patients. The following assessments were conducted: *Prevention of excessive pigmentation induced by UV exposure in Caucasian and Asian skins using a method that measures pigmentation protection factors (PPF). *Efficacy against DNA damage by measurement of pyrimidine dimer formation and p53 protein accumulation. *Protection of immune system using delayed type hypersensitivity (DTH) reactions to recall antigens, isomerization of urocanic acid (UCA), alteration of Langerhans cells (LC) density, morphology and function. *Reduction of epidermal and dermal alterations ...Continue Reading

References

May 1, 1986·Journal of the American Academy of Dermatology·B OrtelH Hönigsmann
Mar 11, 1968·Archives of Biochemistry and Biophysics·M A Pathak, K Stratton
Oct 1, 1996·Photochemistry and Photobiology·A Fourtanier
Mar 18, 2000·Photodermatology, Photoimmunology & Photomedicine·S SeitéA Fourtanier
Oct 6, 2000·Photodermatology, Photoimmunology & Photomedicine·S SeitéB Nusgens
Jun 13, 2002·The Journal of Investigative Dermatology·Johanna M KuchelGary M Halliday
Nov 26, 2002·Experimental Dermatology·Dominique D Moyal, Anny M Fourtanier
Jul 24, 2003·Annals of Epidemiology·Cedric F GarlandEdward D Gorham
Mar 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nita S AgarAlexandra M Jones
Sep 24, 2004·Photodermatology, Photoimmunology & Photomedicine·Dominique Moyal
Aug 23, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·S SeiteG Godeau

❮ Previous
Next ❯

Citations

Jul 31, 2013·Journal of Photochemistry and Photobiology. B, Biology·Julie A Evans-JohnsonC-Y Oliver Chen
Feb 3, 2012·The New England Journal of Medicine·Reinhard DummerSimone M Goldinger
Jan 1, 2010·Journal of Pharmacy & Bioallied Sciences·Daniela RegoAna Grenha
Jun 22, 2012·Indian Journal of Dermatology, Venereology and Leprology·Dominique Moyal
Dec 30, 2014·International Journal of Molecular Sciences·Claire MarionnetFrançoise Bernerd
Feb 5, 2011·Journal of the American Academy of Dermatology·Divya R Sambandan, Desiree Ratner
Dec 18, 2009·The British Journal of Oral & Maxillofacial Surgery·Daryl GoddenJames Milne
Sep 25, 2009·The British Journal of Dermatology·M BylaiteG S Lapinskaite
Sep 27, 2014·International Journal of Cosmetic Science·C Stiefel, W Schwack
Dec 7, 2013·Photodermatology, Photoimmunology & Photomedicine·Jean KrutmannJames Wolffsohn
Oct 3, 2015·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Seunghee BaeSungkwan An
May 2, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·M AdamičP Boixeda
Apr 14, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Guillermo M Zúñiga-GonzálezMartha P Gallegos-Arreola
Oct 30, 2016·Journal of Photochemistry and Photobiology. B, Biology·Guillermo M Zúñiga-GonzálezMartha P Gallegos-Arreola
Jan 27, 2017·International Journal of Food Sciences and Nutrition·C-Y Oliver ChenJonathan Garlick
Feb 7, 2017·Photodermatology, Photoimmunology & Photomedicine·Catherine M OlsenDavid C Whiteman
Sep 9, 2017·Photodermatology, Photoimmunology & Photomedicine·Nancy L MorseMarc St-Onge
Mar 17, 2015·Journal of Cutaneous Medicine and Surgery·Kirk BarberUNKNOWN Canadian Non-melanoma Skin Cancer Guidelines Committee
Nov 14, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Panchada Ch V GovinduKonkallu Hanumae Gowd
Nov 2, 2018·Indian Journal of Dermatology, Venereology and Leprology·Rashmi SarkarMichèle Verschoore
Apr 1, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Dominique Moyal
May 9, 2019·Photochemistry and Photobiology·Mehwish NawazMehrin Farooq
Jul 1, 2014·Current Opinion in Pediatrics·Anh Khoa Pham, James G Dinulos
Jun 18, 2011·Postgraduate Medicine·Sarah A StechschulteDaniel G Federman
Sep 10, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·A FourtanierS Seite
Mar 16, 2017·The Australasian Journal of Dermatology·Francis Hx YapClare P Tait
Mar 1, 2021·Journal of the American Academy of Dermatology·Amaris N GeislerHenry W Lim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Related Papers

Clinics in Dermatology
S GonzalezYolanda Gilaberte-Calzada
International Journal of Pharmaceutics
Maria Valéria Robles VelascoAndré Rolim Baby
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
J R Villalobos-Hernández, C C Müller-Goymann
Dermatologic Clinics
Chanisada TuchindaAndré Rougier
© 2022 Meta ULC. All rights reserved