PMID: 6982289Aug 1, 1982Paper

Sunscreens for delay of ultraviolet induction of skin tumors

Journal of the American Academy of Dermatology
H C WulfK Hou-Jensen

Abstract

Sunscreens with different sun protection factors (SPFs) have been tested for their capability of delaying or preventing actinic damage and skin cancer development in groups of hairless, pigmented mice exposed to artificial ultraviolet (UV) light of increasing intensity. The dose delivered was less than or equal to 1 minimal erythema dose (MED) in the group of untreated mice, so that the mice to which sunscreens were applied never obtained a sunburn after UV exposure. The quality of UV light was similar to bright midday sun at a latitude of 56 degrees (city of Copenhagen). Tumorigenesis was demonstrated to be delayed corresponding to the SPF claimed by the manufacturer, but almost all of the UV-irradiated mice developed skin tumors. Histologic examination revealed actinic degeneration and tumors of squamous cell type with marked variation in differentiation. Metastases to lymph nodes and lungs were found in only 10%. Toxic reactions, such as eczematous-like skin reactions, dark coloring, and amyloidosis, were observed predominantly in the group treated with the sunscreen of highest SPF value. Long-term investigations seem to be necessary to unveil these problems--in particular, the specific SPF value, in sunscreens, that should ...Continue Reading

References

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Citations

Jan 1, 1992·Archives of Dermatological Research·N Bech-ThomsenH C Wulf
Sep 12, 2006·Lasers in Medical Science·L HedelundM Haedersdal
Feb 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·N Bech-ThomsenH C Wulf
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Sep 29, 2012·Photodermatology, Photoimmunology & Photomedicine·Catharina Margrethe LercheHans Christian Wulf
Aug 26, 2009·Experimental Dermatology·Catharina M LercheHans Christian Wulf
Nov 13, 2009·Photodermatology, Photoimmunology & Photomedicine·Katrine Togsverd-BoHans Christian Wulf
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