SUNSET: Stereotactic Radiation for Ultracentral Non-Small-Cell Lung Cancer-A Safety and Efficacy Trial

Clinical Lung Cancer
M E GiulianiDavid Palma

Abstract

Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment for medically inoperable early stage non-small-cell lung cancer (NSCLC). Patients with ultracentral tumors (signifying tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, or pulmonary artery) may be at higher risk of serious toxicities such as bronchial stricture and collapse, esophageal strictures, tracheal-esophageal fistula, and hemorrhage. The primary objective of the study is to determine the maximum tolerated dose of radiotherapy for ultracentral NSCLC. This multicenter phase 1 dose-escalation study will use a time-to-event continual reassessment method (TITE-CRM). Accrual will start at level 1 (60 Gy in 8 fractions delivered daily). The model will use all available information from previously accrued patients to assign the highest dose with a predicted risk of grade 3-5 toxicity of 30% or less. All patients with newly diagnosed stage T1-3 N0M0 NSCLC (International Union Against Cancer, 8th edition) with tumor size ≤ 6 cm and meeting the criteria for ultracentral location (ie, tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, pulmonary vein, or pulmo...Continue Reading

Citations

Sep 25, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mauro LoiMarta Scorsetti
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Oct 30, 2020·International Journal of Radiation Oncology, Biology, Physics·Jeevin ShahiPatrick Cheung
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Apr 7, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Karin LindbergRolf Lewensohn
Apr 27, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Neal AndruskaUNKNOWN Advanced Radiation Therapy Committee for the International Association for the Study of Lung Cancer
Jul 1, 2021·Acta Oncologica·Joyce E LodewegesJoost J C Verhoeff
Sep 22, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Karin Lindberg, Eva Onjukka
Apr 9, 2019·International Journal of Radiation Oncology, Biology, Physics·David PalmaMeredith Giuliani

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