Super high estradiol response to gonadotropin stimulation in patients undergoing in vitro fertilization

Journal of in Vitro Fertilization and Embryo Transfer : IVF
Michael P DiamondA H DeCherney

Abstract

The likelihood of establishment of a term pregnancy from in vitro fertilization (IVF) is related to the estradiol (E2) pattern and peak level. To examine the influence of super high E2 peak levels (greater than or equal to 2000 pg/ml), we reviewed the clinical outcomes of all IVF cycles with follicular phase E2 levels greater than 2000 pg/ml from May 1982 through June 1987. Among 1651 IVF cycles initiated during this time, 102 cycles (6.2%) had super high E2 levels. Twenty-seven of these cycles occurred in 34 IVF attempts in 12 women. Stimulation was performed with human menopausal gonadotropin (hMG) in 96 cycles and follicle-stimulating hormone (FSH) in 6 cycles. A mean of 9.3 +/- 0.7 oocytes per cycle was recovered, of which 5.5 +/- 0.5 fertilized and underwent cleavage. In 11 cycles, with a mean of 6.8 oocytes recovered, none fertilized. Polyploid fertilization occurred in 23 of 90 cycles (25.6%), and 40 of 558 fertilized oocytes (7.2%). From these cycles, 10 clinical pregnancies (9.8%) have resulted: 6 pregnancies in 59 cycles with luteal-phase progesterone support (10.2%) and 4 pregnancies in 31 cycles without luteal-phase progesterone support (12.9%). Among the 1549 cycles with peak E2 levels less than or equal to 2000 pg...Continue Reading

References

Jun 1, 1988·Fertility and Sterility·G LavyA H DeCherney
Apr 1, 1986·Journal of in Vitro Fertilization and Embryo Transfer : IVF·M P DiamondA C Wentz
Oct 1, 1987·Fertility and Sterility·S P BoyersA H DeCherney
Oct 1, 1987·Journal of in Vitro Fertilization and Embryo Transfer : IVF·M P DiamondA C Wentz
Mar 1, 1985·Fertility and Sterility·M P DiamondW S Maxson
Jan 1, 1973·American Journal of Obstetrics and Gynecology·J M Morris, G Van Wagenen
Sep 1, 1983·Fertility and Sterility·A Lopata
Mar 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·N LauferF Naftolin

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Citations

Aug 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·T al-ShawafI Craft
Nov 1, 1993·Journal of Assisted Reproduction and Genetics·M R FlukerS Daya
Aug 1, 1995·Journal of Assisted Reproduction and Genetics·T J Gelety, R P Buyalos
Jan 1, 1991·International Journal of Technology Assessment in Health Care·P A Lancaster
Jun 15, 2004·Fertility and Sterility·Andrew S BlazarDavid L Keefe
Apr 20, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A T BerezowskiS P Cunha
Feb 1, 1996·Journal of Chemotherapy·M Hedberg, C E Nord

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