Super-hydrophilic silicone hydrogels with interpenetrating poly(2-methacryloyloxyethyl phosphorylcholine) networks

Biomaterials
Takanori ShimizuKazuhiko Ishihara

Abstract

We synthesized silicone hydrogels from 2-methacryloyloxyethyl phosphorylcholine (MPC) and bis(trimethylsilyloxy)methylsilylpropyl glycerol methacrylate (SiMA) using two methods: random copolymerization with a small amount of cross-linker (P(SiMA-co-MPC)) and construction of an interpenetration network (IPN) structure composed of cross-linked poly(MPC)(PMPC) chains and cross-linked poly(SiMA)(PSiMA) chains (PSiMA-ipn-PMPC). The polymerization was carried out by photoreaction. The surface hydrophilicity and water absorbability of P(SiMA-co-MPC) increased with an increase in the MPC unit composition. On the other hand, in the case of PSiMA-ipn-PMPC, a super-hydrophilic surface was obtained by the surface enrichment of MPC units. The optical and mechanical properties of PSiMA-ipn-PMPC are suitable for use as a material for preparing contact lenses. In addition, the oxygen permeability of PSiMA-ipn-PMPC remains high because of the PSiMA chains. The MPC units at the surface of the hydrogels reduce protein adsorption effectively. From these results for PSiMA-ipn-PMPC, we confirmed that it has the potential for application to silicone hydrogel contact lenses.

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Citations

Oct 25, 2011·Journal of Materials Science. Materials in Medicine·Jing Jing Wang, Fang Liu
Jun 7, 2013·Biomacromolecules·William G HerrickShelly R Peyton
Jan 1, 2013·Eye & Contact Lens·Nancy Keir, Lyndon Jones
Oct 6, 2015·Advanced Materials·Xiaobo HuSergei S Sheiko
Feb 14, 2012·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Doerte Luensmann, Lyndon Jones
Feb 3, 2016·Chinese Medical Journal·Qi HuangGui-Qin Wang
May 20, 2015·Journal of Colloid and Interface Science·Van-Tien BuiHo-Suk Choi
Dec 31, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Biao YangJijun Huang
Dec 16, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Pengtao WangHongwei Sun
Nov 15, 2018·Angewandte Chemie·Yinqiang XiaXavier Banquy
Oct 18, 2012·Science and Technology of Advanced Materials·Yasuhiko Iwasaki, Kazuhiko Ishihara
May 21, 2019·Journal of Biomaterials Science. Polymer Edition·Hsiu-Wen Chien, Chia-Jung Kuo
Nov 21, 2019·Annals of Biomedical Engineering·Tanmay P LeleShelly R Peyton
Feb 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Samantha McRae PageTodd Emrick
Jan 18, 2021·Drug Delivery and Translational Research·Onyinye J UwaezuokeYahya E Choonara
Dec 1, 2017·Analytical Biochemistry·Ramachandram BaduguJoseph R Lakowicz
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Mark WillcoxLyndon Jones
May 23, 2020·Eye & Contact Lens·Hiroko IwashitaYuichi Hori
May 1, 2021·Pharmaceutics·María Vivero-LopezCarmen Alvarez-Lorenzo
Jan 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Wan-Ju HsuDun-Yen Kang

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