Super-resolution ultrasound imaging method for microvasculature in vivo with a high temporal accuracy

Scientific Reports
Jaesok YuKang Kim

Abstract

Traditional ultrasound imaging techniques are limited in spatial resolution to visualize angiogenic vasa vasorum that is considered as an important marker for atherosclerotic plaque progression and vulnerability. The recently introduced super-resolution imaging technique based on microbubble center localization has shown potential to achieve unprecedented high spatial resolution beyond the acoustic diffraction limit. However, a major drawback of the current super-resolution imaging approach is low temporal resolution because it requires a large number of imaging frames. In this study, a new imaging sequence and signal processing approach for super-resolution ultrasound imaging are presented to improve temporal resolution by employing deconvolution and spatio-temporal-interframe-correlation based data acquisition. In vivo feasibility of the developed technology is demonstrated and evaluated in imaging vasa vasorum in the rabbit atherosclerosis model. The proposed method not only identifies a tiny vessel with a diameter of 41 μm, 5 times higher spatial resolution than the acoustic diffraction limit at 7.7 MHz, but also significantly improves temporal resolution that allows for imaging vessels over cardiac motion.

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Citations

Dec 29, 2020·Ultrasonics·Vincent PerrotDamien Garcia
Dec 14, 2019·Advances in Chronic Kidney Disease·Edward R SmithStephen G Holt
Feb 4, 2021·Biomicrofluidics·Magalí Mercuri, David Fernandez Rivas
Feb 23, 2021·Drug Discovery Today·Anjali SrivastavaShrikant R Mulay
Sep 2, 2020·ACS Nano·Azaam AzizOliver G Schmidt
Oct 1, 2021·Physics in Medicine and Biology·Jingyi YinJue Zhang

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Methods Mentioned

BETA
imaging technique

Software Mentioned

MATLAB
STIC
ImageJ
Verasonics

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