Superabsorbent Polymer Microspheres Prepared with Hypertonic Saline to Reduce Microsphere Expansion

Cardiovascular and Interventional Radiology
Takeshi SatoKimihiko Kichikawa

Abstract

To analyze size changes of superabsorbent polymer (SAP) microspheres with the reduced expansion technique, and to evaluate pharmacological advantages of transarterial chemoembolization using cisplatin-loaded SAP microspheres with the reduced expansion technique. In an in vitro study, diluted contrast materials containing different concentrations of sodium ions were examined to expand SAP microspheres and determined the reduced expansion technique. Size distributions of cisplatin-loaded SAP microspheres were analyzed. In an in vivo study, TACE was performed using cisplatin-loaded SAP microspheres with the reduced expansion and control techniques in 18 VX2 rabbits. The degree of expansion was reduced to the greatest extent by using a mixture of non-ionic contrast material and 10% NaCl at a 4:1 ratio. The mean diameter of the reduced expansion of cisplatin-loaded SAP microspheres was 188.4 μm, while that of the control expansion was 404.9 μm. The plasma platinum concentrations of the reduced expansion group at 5 min after TACE were significantly higher than those of the control expansion group (2.19 ± 0.77 vs. 0.75 ± 0.08 μg/mL, P = .01). The tumor platinum concentrations of the reduced expansion group at 1 h were significantly hi...Continue Reading

References

Oct 3, 2003·Japanese Journal of Clinical Oncology·Sotaro SadahiroChieko Murayama
Apr 24, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaharu YoshikawaHironobu Nakamura
Apr 27, 2010·Journal of Vascular and Interventional Radiology : JVIR·Noboru MaedaHironobu Nakamura
Dec 20, 2011·Journal of Vascular and Interventional Radiology : JVIR·Matthew R DreherBradford J Wood
Feb 24, 2012·Cardiovascular and Interventional Radiology·Pramod P RaoThierry de Baere
Jul 28, 2013·Journal of Vascular and Interventional Radiology : JVIR·Arthur J RichardsonVincent W T Lam
May 28, 2014·Journal of Vascular and Interventional Radiology : JVIR·Toshihiro TanakaKimihiko Kichikawa

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