Superantigen-induced TCR alpha locus secondary rearrangement: role in tolerance induction

The Journal of Immunology : Official Journal of the American Association of Immunologists
Ching-Yu HuangO Kanagawa

Abstract

Immunization with superantigen in vivo induces transient activation of superantigen-specific T cells, followed by a superantigen-nonresponsive state. In this study, using a TCR alpha knock-in mouse in which the knock-in alpha-chain can be replaced with endogenous alpha-chain through secondary rearrangement, we show that immunization of superantigen changes the TCR alpha-chain expression on peripheral superantigen-specific T cells, induces expression of recombination-activating genes, and generates DNA double-strand breaks at the TCR alpha-chain locus. These results suggest that viral superantigens are capable of inducing peripheral TCR revision. Our findings thus provide a new perspective on pathogen-immune system interaction.

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Citations

Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristine J CooperPamela J Fink
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mitsuyo TakaseOsami Kanagawa
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Oct 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Scott HalePamela J Fink
Apr 27, 2002·Nature Immunology·Jonathan SprentPamela J Fink
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Lauren E HigdonPamela J Fink
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dietmar ZehnPamela J Fink
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristine J CooperPamela J Fink
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Nov 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Pau SerraPere Santamaria
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed AliPamela J Fink
Jul 16, 2020·The Journal of Experimental Medicine·Agata CieslakVahid Asnafi
Apr 13, 2011·Molecular Immunology·Luca OrlandoClaudia Giachino

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