Superantigen-like effects of a Candida albicans polypeptide.

The Journal of Infectious Diseases
Denise Devore-CarterM K Hostetter

Abstract

The amino terminal sequence of the Candida albicans cell wall protein Int1 exhibited partial identity with the major histocompatibility complex (MHC) class II binding site of the Mycoplasma arthritidis superantigen MAM. Int1-positive C. albicans blastospores activated human T lymphocytes and expanded Vbeta subsets 2, 3, and/or 14; Int1-negative strains were inactive. Release of interferon-gamma (IFN-gamma) but not of tumor necrosis factor-alpha or interleukin-6 was Int1 dependent; interleukin-4 and interleukin-10 were not detected. T lymphocyte activation, Vbeta expansion, and IFN-gamma release were associated with a soluble polypeptide that encompassed the first 263 amino acids of Int1 (Pep(263)). Monoclonal antibody 163.5, which recognizes an Int1 epitope that overlaps the region of identity with MAM, significantly inhibited these activities when triggered by Int1-positive blastospores or Pep(263) but not by staphylococcal enterotoxin B. Histidine(263) was required. Pep(263) bound to T lymphocytes and MHC class II and was detected in the urine of a patient with C. albicans fungemia. These studies identify a candidal protein that displays superantigen-like activities.

References

May 11, 1995·Nucleic Acids Research·M A Santos, M F Tuite
Mar 1, 1995·Antimicrobial Agents and Chemotherapy·K V Clemons, D A Stevens
Aug 25, 1993·Nucleic Acids Research·T OhamaT Nakase
Jan 1, 1993·Advances in Immunology·B L KotzinP Marrack
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·C GaleM Hostetter
Dec 1, 1998·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·M NucciN Spector
Jun 8, 1999·Annual Review of Immunology·H LiR A Mariuzza
Sep 7, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M B EdmondR P Wenzel
Jan 11, 2000·Molecular and Cellular Biology·D DavisA P Mitchell
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R J HoganD L Woodland
Nov 6, 2001·Molecular Biology of the Cell·C GaleJ Berman
May 7, 2002·The Journal of Infectious Diseases·Mihai G NeteaBart Jan Kullberg
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN NIAID Mycoses Study Group
Jul 1, 1959·A.M.A. Archives of Internal Medicine·A I BRAUDE, J A ROCK
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Theoklis E ZaoutisChris Feudtner
May 3, 2006·PLoS Pathogens·Robert T Wheeler, Gerald R Fink

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Citations

Aug 2, 2013·The Journal of Infectious Diseases·Julianne V GreenMargaret K Hostetter
Mar 5, 2011·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Shinji Kagami
Sep 23, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Yukako YoshikaneKoichi Yoshimura
Jul 19, 2019·Frontiers in Pediatrics·Akihiro NakamuraKenji Hamaoka

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