Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review

Advanced Drug Delivery Reviews
Luís PadrelaHermínio C de Sousa

Abstract

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of inadequate drug dissolution rates, is one of the most significant challenges that pharmaceutical companies are currently facing, since this may limit the therapeutic efficacy of marketed drugs, or even result in the discard of potential highly effective drug candidates during developmental stages. Two of the main approaches that have been implemented in recent years to overcome poor drug solubility/dissolution issues have frequently involved drug particle size reduction (i.e., micronization/nanonization) and/or the modification of some of the physicochemical and structural properties of poorly water soluble drugs. A large number of particle engineering methodologies have been developed, tested, and applied in the synthesis and control of particle size/particle-size distributions, crystallinities, and polymorphic purities of drug micro- and nano-particles/crystals. In recent years pharmaceutical processing using supercritical fluids (SCF), in general, and supercritical carbon dioxide (scCO2), in particular, have attracted a great attention from the pharmaceutical industry. This is mostly due to the several well-known advantageous technica...Continue Reading

Citations

Jan 10, 2019·Pharmaceutics·Soon Hong Soh, Lai Yeng Lee
Mar 7, 2020·Frontiers in Bioengineering and Biotechnology·Pablo Vega-VásquezJoseph Irudayaraj
Mar 7, 2020·Polymers·Víctor Santos-RosalesCarlos A García-González
Sep 9, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Baiji XueXuefeng Li
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Sep 9, 2020·International Journal of Pharmaceutics·Tingting ChenQingguo Li
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Antonio Tabernero, Stefano Cardea
Mar 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chen ZhaoHaifeng Liu
Feb 19, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carlos A García-GonzálezCarmen Alvarez-Lorenzo
Apr 13, 2021·Advanced Drug Delivery Reviews·Dongmei CunMingshi Yang
May 17, 2021·International Journal of Pharmaceutics·Vivek VermaLuis Padrela
Jun 12, 2021·Frontiers in Chemistry·Mukesh MeenaPriyankaraj Sonigra
Nov 11, 2020·International Journal of Pharmaceutics·Vivek VermaLuis Padrela

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