PMID: 9524707Apr 3, 1998Paper

Superficial extremity soft tissue sarcoma: an analysis of prognostic factors

Annals of Surgical Oncology
A D BrooksM F Brennan

Abstract

Experience with soft tissue sarcoma has suggested that superficial tumors have a favorable prognosis. We evaluated the prognostic features of this subset of sarcoma. Prospective data on 215 patients presenting to Memorial Sloan-Kettering Cancer Center with primary extremity superficial soft tissue sarcomas between July 1, 1982 and July 1, 1996 were analyzed. Superficial sarcomas were defined as subcutaneous tumors not invading the investing fascia of the muscle. Analysis was by univariate and multivariate tests for local recurrence, metastasis, and tumor mortality. Ninety (42%) patients were over 50 years of age, 115 (53%) had high-grade tumors, 53 (25%) had tumors > or = 5 cm, and 18 (8%) had positive margins following definitive resection. Median follow-up was 45 months (range 2 days to 151 months), 31 (14%) patients had local recurrences, 20 (9%) had distant metastases, and 15 (7%) died of disease. Five- and 10-year actuarial disease-specific survivals were 91% and 85%, respectively. On multivariate analysis, age > 50 years predicted local recurrence (RR 5.7; 95% CI, 2.4-13.3; p < 0.0001). High grade (RR 4.2; 95% CI, 1.4-12.7; p < 0.006), and size > or = 5 cm (RR 4.4; 95% CI, 1.8-11; p < 0.002) predicted distant metastases. ...Continue Reading

References

Nov 1, 1992·Archives of Surgery·R J GeerM F Brennan
Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J GaynorM F Brennan
Oct 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A RydholmT Alvegård
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Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J LewisM F Brennan

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Citations

Sep 5, 2002·Cancer·Patrick P LinAlan W Yasko
Jan 13, 2009·The Journal of the American Academy of Orthopaedic Surgeons·Nathan F GilbertValerae O Lewis
Jan 4, 2012·Journal of Surgical Oncology·Satoshi TsukushiNaoki Ishiguro
Dec 22, 2017·Plastic and Reconstructive Surgery. Global Open·William C EwardJay S Wunder
Aug 1, 2020·The Bone & Joint Journal·Tomohiro FujiwaraAdesegun Abudu
Jul 23, 2003·Current Opinion in Oncology·Stephen R Grobmyer, Murray F Brennan
May 28, 2019·Current Treatment Options in Oncology·Makoto EndoYoshihiro Matsumoto
Apr 23, 2019·Current Opinion in Pediatrics·Gideon SandlerAndrea Hayes-Jordan
Jul 23, 1999·Current Opinion in Oncology·L Y Dirix, A T Van Oosterom
Jan 1, 2012·Revista Brasileira De Ortopedia·Jorge Sayum FilhoMoisés Cohen
Feb 1, 2018·Asia-Pacific Journal of Clinical Oncology·Mark Ting Le TanPhilip J Crowe
Sep 1, 2005·Clinical Orthopaedics and Related Research·Bruce T RougraffTerence Cudahy
Feb 16, 2021·Clinics in Perinatology·Tooba RashidMichael D Deel
May 16, 2019·Current Opinion in Pediatrics·Gideon SandlerAndrea Hayes-Jordan

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