Superficial photothermal laser ablation of ex vivo sheep esophagus using a cone-shaped optical fiber tip.

Journal of Biophotonics
Serhat Tozburun

Abstract

Superficial photothermal laser ablation (SPLA) may be useful as a therapeutic approach producing a depth of injury that is sufficient to eliminate mucosal lesion but not deep enough to induce thermal effects in deeper tissue layers. The purpose of this preliminary study is twofold: (a) to describe design steps of a fiber probe capable of delivering a tightly focused laser beam, including Monte-Carlo-based simulations, and (b) to complete the initial testing of the probe in a sheep esophagus model, ex vivo. The cone-shaped (tapered) fiber tip was obtained by chemical etching of the optical fiber. A 1505 nm diode laser providing power up to 500 mW was operated in continuous wave. The successful SPLA of the sheep mucosa layer was demonstrated for various speed-power combinations, including 300 mW laser power at a surface scanning rate of 0.5 mm/s and 450 mW laser power at a surface scanning rate of 2.0 mm/s. Upon further development, this probe may be useful for endoscopic photothermal laser ablation of the mucosa layer using relatively low laser power.

References

Jul 1, 1995·Computer Methods and Programs in Biomedicine·L WangL Zheng
Jun 1, 1995·Gastrointestinal Endoscopy·D K TaniguchiF E Silverstein
Feb 1, 1996·Gastroenterology·S J Spechler, R K Goyal
Jan 11, 2000·Ultramicroscopy·B A Puygranier, P Dawson
Sep 18, 2003·Journal of the National Cancer Institute·Lawrence S EngelJoseph F Fraumeni
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Apr 17, 2004·Journal of Gastroenterology and Hepatology·Murat TorunerAli Ozden
Aug 24, 2004·Journal of Applied Physiology·Christopher M CollinsRobert Turner
May 13, 2005·Gut·H BarrB Rembacken
Dec 14, 2005·Gastroenterology·Jukka RonkainenLars Agréus
Mar 23, 2007·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Jason K Lee, Robert Enns
Feb 4, 2009·Digestive Diseases·David E Fleischer, Virender K Sharma
Feb 7, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T W RiceE H Blackstone
Jun 12, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·B OdemişO Yüksel
Aug 28, 2009·Surgical Endoscopy·Melina C VassiliouRichard I Rothstein
Oct 1, 2009·Lasers in Surgery and Medicine·Thomas M GlanzmannGeorges A Wagnières
Mar 1, 1973·Applied Optics·G M Hale, M R Querry
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Kwong Ming Fock, Tiing Leong Ang
Nov 28, 2012·World Journal of Gastroenterology : WJG·Giovanni D De Palma
Feb 12, 2014·Optics Express·Jean-Baptiste DecombeJochen Fick
Aug 19, 2014·World Journal of Gastrointestinal Pharmacology and Therapeutics·Raul Badillo, Dawn Francis
Nov 4, 2015·The American Journal of Gastroenterology·Nicholas J ShaheenUNKNOWN American College of Gastroenterology
Oct 19, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael ViethRoberto Fiocca
May 4, 2017·Journal of Biophotonics·Martin HohmannH Albrecht
Jul 9, 2017·Journal of Biomedical Optics·Hsiang-Chieh LeeJames G Fujimoto
Jan 4, 2018·Biomedical Optics Express·Van Gia TruongHyun Wook Kang

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