SuperFly: a comparative database for quantified spatio-temporal gene expression patterns in early dipteran embryos

Nucleic Acids Research
Damjan Cicin-SainJohannes Jaeger

Abstract

We present SuperFly (http://superfly.crg.eu), a relational database for quantified spatio-temporal expression data of segmentation genes during early development in different species of dipteran insects (flies, midges and mosquitoes). SuperFly has a special focus on emerging non-drosophilid model systems. The database currently includes data of high spatio-temporal resolution for three species: the vinegar fly Drosophila melanogaster, the scuttle fly Megaselia abdita and the moth midge Clogmia albipunctata. At this point, SuperFly covers up to 9 genes and 16 time points per species, with a total of 1823 individual embryos. It provides an intuitive web interface, enabling the user to query and access original embryo images, quantified expression profiles, extracted positions of expression boundaries and integrated datasets, plus metadata and intermediate processing steps. SuperFly is a valuable new resource for the quantitative comparative study of gene expression patterns across dipteran species. Moreover, it provides an interesting test set for systems biologists interested in fitting mathematical gene network models to data. Both of these aspects are essential ingredients for progress toward a more quantitative and mechanisti...Continue Reading

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Citations

Jan 23, 2016·Molecular Biology and Evolution·Anton CrombachJohannes Jaeger
Jul 12, 2016·Current Opinion in Genetics & Development·Urs Schmidt-Ott, Jeremy A Lynch
Oct 3, 2019·Proceedings. Biological Sciences·Ariel D Chipman, Gregory D Edgecombe

Methods Mentioned

BETA
RNA-seq

Related Concepts

Metazoa
Diptera
Drosophila melanogaster
Embryonic Structures, Nonmammalian
Gene Expression
Twitter Messaging
Online Mendelian Inheritance In Man
Embryo
Biological Evolution
Genes

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