Superinfection by homotypic virus in hepatitis C virus carriers: studies on patients with post-transfusion hepatitis

Journal of Medical Virology
J H KaoD S Chen

Abstract

Although heterotypic superinfection and mixed infections of hepatitis C virus (HCV) may be possible for hepatitis flares in chronic hepatitis C, the possibility of homotypic HCV superinfection in HCV carriers with post-transfusion hepatitis has not been explored. Six HCV carriers with post-transfusion non-A, non-B hepatitis found in a prospective study of post-transfusion hepatitis were included. Serum samples before transfusion and during hepatitis were selected to determine genotypes of HCV and nucleotide sequences of the hypervariable region (HVR). The genotypes identified before and after transfusion were concordant in all. There were four with type 1b and one each with type 2a and type 2b. Amplified nucleotide sequences of the HVR before transfusion and during hepatitis were compared in four patients, and a > 95% homology was observed in three, suggesting persistence of original viruses. In contrast, only a 51% homogeneity was seen in a given patient, suggesting a homotypic HCV superinfection. Phylogenetic tree analysis validated further these findings. This study implies that HCV carriers can be reinfected by homotypic HCV, and this may contribute to hepatitis flares in chronic hepatitis C. These findings also confirm a w...Continue Reading

References

Mar 1, 1992·The Journal of Infectious Diseases·A M PrinceG Inchauspé
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M HoughtonQ L Choo
Jan 1, 1990·Journal of Gastroenterology and Hepatology·H J Alter
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KiyosawaR H Purcell
May 18, 1989·Nature·S Kwok, R Higuchi
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J ChenJ L Sung
Feb 1, 1995·Seminars in Liver Disease·J BukhR H Purcell
Sep 4, 1993·Lancet·J H KaoD S Chen
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OkamotoM Mayumi
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SimmondsD S Chen
Mar 1, 1993·Journal of Gastroenterology and Hepatology·K ChayamaS Koyama
Oct 1, 1995·Journal of Clinical Gastroenterology·J H KaoD S Chen
Jun 1, 1994·Journal of Biomedical Science·J.-H. KaoD.-S. Chen

❮ Previous
Next ❯

Citations

Jul 7, 2001·The New England Journal of Medicine·G M Lauer, B D Walker
Oct 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason GrebelyUNKNOWN ATAHC Study Group
Aug 12, 2006·Journal of Viral Hepatitis·F BernardinE Delwart
Nov 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Son T PhamPeter A White
Jan 18, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·C Neumann-HaefelinR Thimme
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Jia-Horng Kao, Ding-Shinn Chen
Jul 9, 2002·Journal of Gastroenterology and Hepatology·Jia-Horng Kao
Sep 26, 2006·Journal of Medical Virology·Seiji KageyamaHiroshi Ichimura
Mar 18, 2015·Nature Reviews. Gastroenterology & Hepatology·Evan B CunninghamJason Grebely
Sep 26, 2003·Transfusion·Eva A OperskalskiUNKNOWN Retrovirus Epidemiology Donor Study

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.