Superior antiplatelet action of alternate day pulsed dosing versus split dose administration of aspirin

The American Journal of Cardiology
R L LorenzP C Weber

Abstract

To explore the effect of timing on the antiplatelet action of aspirin, a constant mean amount of 40 mg aspirin/day was administered either as a split regimen of 20 mg twice daily, a single dose of 40 mg or a doubled dose of 80 mg every other day for 1 week each and compared to a current standard low dose regimen of 324 mg/day. Bleeding time, serum thromboxane, collagen-stimulated platelet aggregation and associated thromboxane formation and excretion of thromboxane and prostacyclin metabolites were measured both at peak and trough action of the drug. The inhibitory effects on platelet aggregation and associated thromboxane formation were significantly less marked with the split dose regimen, intermediate with the single dose of 40 mg aspirin/day and best with the alternate day doubled dose, but still inferior to the effects of 324 mg/day. Thromboxane excretion was suppressed by greater than 80% with all regimens. Prostacyclin metabolite excretion was similar for all 40 mg/day regimens with about 40% suppression at trough and 60% at peak drug action, respectively. Suppression was more pronounced after 324 mg/day. For best platelet inactivation at comparable sparing of prostacyclin formation, low doses of aspirin should be admini...Continue Reading

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J W BurchP W Majerus
Mar 1, 1979·The Journal of Clinical Investigation·E A Jaffe, B B Weksler
Jan 28, 1988·The New England Journal of Medicine·UNKNOWN Steering Committee of the Physicians' Health Study Research Group
Apr 1, 1987·Australian and New Zealand Journal of Medicine·C M HerdL J Tunbridge
Dec 1, 1985·Circulation·C PatronoL Forni
Aug 1, 1963·The Journal of Physiology·G V BORN, M J CROSS

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Citations

Oct 17, 1991·The New England Journal of Medicine·R J ClarkeG A FitzGerald
Nov 4, 1995·Journal of Interventional Cardiology·G C Timmis, E Terrien
Jun 1, 1995·Chest·J SimmonsK M Kessler
Feb 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W HoffmannW Förster
Nov 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W Hoffman, W Förster
Nov 23, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Xiaomin KangAimin Zhao
Sep 2, 2017·Epidemiology·Wen-Yi HuangSonja I Berndt
Apr 16, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Tongfei WangFangsun Liu
Mar 10, 2007·Human Reproduction Update·T A GelbayaL G Nardo
Nov 1, 1993·Artificial Organs·R L JaarsmaD B Olsen
Jul 10, 2019·Frontiers in Cardiovascular Medicine·Marleen BuurmaTobias N Bonten

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