Superior cervical ganglion regenerating axons through peripheral nerve grafts and reversal of behavioral deficits in hemiparkinsonian rats

Journal of Neurosurgery
R PalliniG F Rossi

Abstract

The superior cervical ganglion (SCG) has been grafted to the brain of adult rats in an attempt to reverse the parkinsonian syndrome that follows destruction of central dopamine systems. However, the main limitation to this approach is the massive cell death that occurs in the grafted SCG after direct transplantation into the brain. In adult rats, 6-hydroxydopamine (6-OHDA) was stereotactically injected into the right substantia nigra (SN). One month later, dopamine denervation was assessed using the apomorphine-induced rotational test. In rats with a positive test, an autologous peripheral nerve (PN) graft was tunneled from the right cervical region to the ipsilateral parietal cortex. One end of PN graft was sutured to the transected postganglionic branch of the SCG and the other end was inserted into a surgically created cortical cavity. The apomorphine test was repeated at 3 days and again at 1, 3, and 5 months after surgery. The brain, SCG, and PN graft were studied under light and electron microscopy and with the tyrosine hydroxylase immunohistochemical and horseradish peroxidase tracing methods. Three days after grafting, there were no significant differences on the apomorphine test as compared to the preoperative test. Co...Continue Reading

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Citations

Aug 23, 2005·Brain Research. Brain Research Reviews·Emilio Fernandez-EspejoSusana Ramiro
Mar 17, 2017·Journal of Neurosurgery·Panagiotis MastorakosMark E Shaffrey
May 4, 2010·Journal of Neurosurgery. Pediatrics·Garrett K ZoellerDavid I Sandberg
Apr 16, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Bettina WabbelsBirgit Lorenz
Feb 22, 2012·Brain Tumor Pathology·Doreen LemmElisabeth J Rushing
Apr 1, 2012·Neuro-ophthalmology·Joann J KangHeather E Moss

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Methods Mentioned

BETA
dissection
light microscopy

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