Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice

Biomedical Reports
Ahmet MutluPelin Tanyeri

Abstract

Cognitive dysfunction is commonly observed in schizophrenic patients and the administration of antipsychotic treatments results in different outcomes. Although the typical antipsychotic treatments, such as haloperidol, appear to be unable to improve cognition dysfunction, the atypical antipsychotic drugs (quetiapine, aripiprazole and iloperidone) exert a beneficial effect. The purpose of the current study was to investigate the effects of atypical antipsychotics on olfactory memory in mice, utilizing the social transmission of food preference (STFP) tests to evaluate the effects of drugs on MK-801-induced cognitive dysfunction. Female BALB/c mice were treated with quetiapine (5 and 10 mg/kg), aripiprazole (3 and 6 mg/kg), iloperidone (0.5 and 1 mg/kg) or MK-801 (0.1 mg/kg) alone or concurrently prior to retention sessions of STFP tests. In the STFP tests, quetiapine (10 mg/kg; P<0.05), aripiprazole (3 and 6 mg/kg; P<0.01 and P<0.001, respectively), iloperidone (0.5 and 1 mg/kg; P<0.01 and P<0.001, respectively) and MK-801 (P<0.001) significantly decreased cued/total food eaten (%). Quetiapine (5 mg/kg; P<0.05) significantly increased MK-801-induced decreases in cued/total food eaten (%), while aripiprazole and iloperidone demon...Continue Reading

References

Jun 23, 2011·Pharmacology, Biochemistry, and Behavior·Oguz MutluPelin Tanyeri
Apr 6, 2013·Medical Hypotheses·Arnold E Eggers
Oct 9, 2013·The International Journal of Neuropsychopharmacology·Herbert Y MeltzerMasakuni Horiguchi
May 10, 2015·British Medical Bulletin·John Lally, James H MacCabe
May 25, 2016·The Psychiatric Clinics of North America·Ganesh GopalakrishnaJohn Lauriello
Jun 15, 2016·Human Psychopharmacology·Massimiliano BuoliWiepke Cahn

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