Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing

Light, Science & Applications
Srdjan S AćimovićMikael Käll

Abstract

Localized surface plasmon resonance (LSPR) biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization, multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic environment. However, such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption, which must be carefully blocked to avoid compromising the device readings. To address this issue, we made the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized wet-etching. The resulting LSPR substrate, which consists of gold nanodisks centered on narrow SiO2 pillars, exhibits markedly reduced vulnerability to nonspecific substrate adsorption, thus allowing, in an ideal case, the implementation of thicker and more efficient passivation layers. We demonstrate that this approach is effective and fully compatible with state-of-the-art multiplexed real-time biosensing technology and thus represents the ideal substrate design for high-throughput label-free biosensing systems with minimal sample consump...Continue Reading

References

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Citations

Oct 31, 2019·The Analyst·Elba MaurizLaura M Lechuga
Nov 18, 2020·Nature Communications·Nareg OhannesianWei-Chuan Shih
Apr 4, 2021·Sensors·Paulo S S Dos SantosLuís C C Coelho
Sep 4, 2019·ACS Nano·Judith LangerLuis M Liz-Marzán
Jan 28, 2020·ACS Nano·Ferry Anggoro Ardy NugrohoChristoph Langhammer
Sep 13, 2018·ACS Applied Materials & Interfaces·Justin R SperlingAlasdair W Clark
Jul 18, 2020·ACS Applied Materials & Interfaces·Ze YinLimei Tian
May 12, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Tien-Jung LeeChun-Jen Huang
Oct 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ainash Garifullina, Amy Q Shen

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
biosensing
chip

Software Mentioned

Labview

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