Superior olivary contributions to auditory system plasticity: medial but not lateral olivocochlear neurons are the source of cochleotomy-induced GAP-43 expression in the ventral cochlear nucleus

The Journal of Comparative Neurology
K S Kraus, R B Illing

Abstract

A unilateral cochlear lesion induces expression of the growth and plasticity-associated protein 43 (GAP-43) in fibers and their varicosities on specific types of postsynaptic profiles in the ventral cochlear nucleus (VCN), suggesting the induction of synaptic remodeling. One candidate population from which GAP-43 might emerge was neurons of the lateral olivocochlear (LOC) system residing in the lateral superior olive (LSO). Upon cochleotomy, these neurons express GAP-43 mRNA and GAP-43 protein. However, retrograde axonal tracing with Fast Blue or biotinylated dextran amine from VCN revealed that the number of 6.8 +/- 1.3 neurons in the whole ipsilateral LSO labeled in normal adult rats was distinctly small and did not rise after cochleotomy. Concluding that LOC neurons cannot be the source of GAP-43 in the VCN, we reinvestigated the pattern of GAP-43 in situ hybridization and found that, after cochleotomy, shell neurons in the regions surrounding the LSO and medial olivocochlear (MOC) neurons in the ventral nucleus of the trapezoid body up-regulated GAP-43 mRNA. We then lesioned these regions by means of stereotaxic injections of kainic acid. Destruction of shell neurons preceding an ipsilateral cochleotomy did not change the e...Continue Reading

References

Sep 7, 1979·Brain Research·W B Warr, J J Guinan
Oct 26, 1979·Brain Research·J R GaddyH J Haigler
Aug 1, 1976·The Journal of the Acoustical Society of America·P Dallos, M A Cheatham
Jan 1, 1991·Synapse·D E VetterE Mugnaini
Jan 1, 1991·Neuroscience·J W DaniL I Benowitz
Jan 1, 1991·Neuron·E E Baetge, J P Hammang
Jan 1, 1991·Progress in Brain Research·L I Benowitz, N I Perrone-Bizzozero
Jan 1, 1990·Progress in Brain Research·L I BenowitzW Rodriguez
May 1, 1990·The Journal of Comparative Neurology·T E Benson, M C Brown
Jan 1, 1989·Annual Review of Neuroscience·J H Skene
Nov 11, 1985·Neuroscience Letters·P N de GraanW H Gispen
Dec 22, 1988·The Journal of Comparative Neurology·M C BrownD K Ryugo
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 11, 1985·Science·W E BrownellY de Ribaupierre
Apr 10, 1983·The Journal of Comparative Neurology·J C Adams
Sep 10, 1983·The Journal of Comparative Neurology·J S White, W B Warr
Dec 10, 1983·The Journal of Comparative Neurology·J J GuinanB E Norris
Jan 1, 1983·Hearing Research·H Davis
Mar 1, 1983·Hearing Research·R Rajan, B M Johnstone
Jan 1, 1982·Archives of Oto-rhino-laryngology·M Handrock, J Zeisberg
Oct 16, 1980·Nature·D Purves
Apr 2, 1993·Brain Research·N RajakumarB A Flumerfelt
Jan 29, 1996·The Journal of Comparative Neurology·T E BensonM C Brown
Feb 1, 1997·Trends in Neurosciences·L I Benowitz, A Routtenberg

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Citations

Apr 3, 2009·Experimental Brain Research·Michaela FredrichRobert-Benjamin Illing
Mar 22, 2014·PloS One·Nicole Rosskothen-Kuhl, Robert-Benjamin Illing
Oct 11, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Stefan ReussStephan Wolpert
Apr 8, 2014·The European Journal of Neuroscience·Ben CoomberMark N Wallace
Aug 6, 2005·Hearing Research·Robert-Benjamin IllingMarkus A Meidinger
Mar 26, 2015·Frontiers in Neurology·Ben CoomberMark Nelson Wallace
Dec 15, 2015·The Journal of Comparative Neurology·Marcelo Gómez-Álvarez, Enrique Saldaña
Feb 23, 2010·Neuroreport·Michaela Fredrich, Robert-Benjamin Illing
Aug 12, 2005·Journal of Neurophysiology·Christian J SumnerSusan E Shore
Nov 25, 2005·Journal of Neuroscience Research·Yong-Ming Jin, Donald A Godfrey
Jul 5, 2019·Brain and Behavior·Josef HeusingerRobert-Benjamin Illing
Feb 10, 2021·Developmental Neurobiology·David C KohrmanGabriel Corfas
Mar 7, 2021·Hearing Research·Amanda M LauerPaul H Delano

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