Superior single nucleotide polymorphisms that contribute to two main routes of the fatty acid synthesis pathway in Korean cattle

Genes & Genomics
J H LeeKyudong Han

Abstract

The fatty acid composition of adipose tissue in livestock has been recognized as an important carcass trait that affects meat quality. To determine the overall positive effect on fatty acid synthesis, we investigated PPARγ, SREBPs, FABP4, SCD, and FASN genes because SNP and/or SNP combinations were strongly affecting each fatty acid synthesis pathway. We screened their SNPs, SNP combinations, and genotype. Furthermore, we studied the economic traits C18:1, monounsaturated fatty acid (MUFA), and marbling score (MS). To enhance the accuracy of the predictive genetic effect, we applied a statistical adjustment model excluding environmental factors. We also selected superior genes, gene combinations, and genotypes for each economic trait by using multifactor dimensionality reduction. Based on the results, g.3977-325 T>C (CC) was selected as the best genotype of the SNP and the combination (g.10153 A>G, g.3977-325 T>C) (AACC, AGCC, GGCC), (g.3690 G>A, g.3977-325 T>C) (GGCC, GACC), (g.3977-325 T>C, g.25670 C>T) (CCCC, CCCT, CCTT) (genotypes of the best SNP combination) was selected as the best gene combination for C18:1 and MUFA. In addition, g.3977-325 T>C (CC) was selected as the best genotype of the SNP and the combination (g.3977...Continue Reading

References

Oct 9, 1970·Biochemical and Biophysical Research Communications·J C LaRosaD S Fredrickson
Apr 3, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Masaaki TaniguchiSoichi Tsuji
Feb 17, 2007·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·V ChoudharyA Shukla
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Hideki OhsakiHideyuki Mannen
Aug 1, 1997·Meat Science·P G van der WalB Hulsegge
Oct 1, 2003·Meat Science·K RobbinsM S Brewer

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