Superiority of C-11 acetate compared with F-18 fluorodeoxyglucose in predicting myocardial functional recovery by positron emission tomography in patients with acute myocardial infarction

The American Journal of Cardiology
P J RubinR J Gropler

Abstract

In patients with chronic coronary artery disease, preservation of myocardial oxidative metabolism measured by positron emission tomography (PET) with 11C-acetate is a more accurate predictor of subsequent myocardial functional recovery than is maintenance of glucose metabolism estimated with 18F-fluorodeoxyglucose. However, whether measurements of myocardial oxidative metabolism are more accurate than measurements of glucose metabolism in predicting functional recovery in patients with recent myocardial infarction is unknown. Myocardial oxidative metabolism was measured within 10 days of infarction in 19 patients by analysis of the rate of myocardial clearance of 11C-acetate. Metabolism of glucose was assessed by analysis of the uptake of 18F-fluorodeoxyglucose. Criteria for prediction of the recovery of function based on measurements of oxidative metabolism and glucose metabolism were compared. Threshold criteria with 11C-acetate exhibited superior positive and negative predictive values (89% and 73%, respectively) compared with the criteria of 18F-fluorodeoxyglucose (65% and 57%, respectively) (p <0.025). In addition, the magnitude of functional recovery after revascularization correlated with the severity of the metabolic ab...Continue Reading

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Citations

Jan 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Liesbet MesottenLuc Mortelmans
Feb 4, 2014·Current Cardiovascular Imaging Reports·Masanao Naya, Nagara Tamaki
Dec 19, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Chun-Yi WuHsin-Ell Wang
Jun 29, 2002·Nuclear Medicine and Biology·Stephen M MoerleinMichael J Welch
Dec 10, 2003·Current Cardiology Reports·Robert J Gropler, Pablo Soto
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Jul 9, 2003·Annals of Nuclear Medicine·Ichiro MatsunariKinichi Hisada
Feb 19, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Robert J Gropler
Mar 21, 2007·Circulation·Marcelo F Di Carli, Rory Hachamovitch
Jun 3, 2015·Nuclear Medicine Communications·Ismet Sarikaya
Aug 9, 2019·Current Opinion in Cardiology·Shaden KhalafMouaz H Al-Mallah
Jun 4, 2017·Heart Failure Reviews·Abdelrahman JamielMouaz H Al-Mallah

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