Superiority of HMPAO ictal SPECT to ECD ictal SPECT in localizing the epileptogenic zone

Epilepsia
Dong Soo LeeMyung Chul Lee

Abstract

We examined diagnostic performances of Tc-99m hexamethylpropylene amine oxime (HMPAO) and Tc-99m electron capture detection (ECD) ictal single-photon emission computed tomography (SPECT) to localize the epileptogenic zones in mesial temporal lobe epilepsy (TLE) and neocortical epilepsy (NE). Epileptogenic zones were identified by invasive EEG or surgical outcome. Ictal SPECT was performed with stabilized Tc-99m HMPAO (TLE, 17; NE, 23) and with Tc-99m ECD (TLE, 7; NE, 7). Single-blind visual interpretation was used to localize the epileptogenic zones. Asymmetric index was calculated. Subtraction ictal SPECT was coregistered to a magnetic resonance imaging (MRI) template. In TLE, the sensitivity of Tc-99m HMPAO SPECT was 82% (14 of 17) and that of Tc-99m ECD SPECT was 71% (five of seven). The asymmetric index (AI; 25 +/- 10) of Tc-99m HMPAO SPECT was larger (p = 0.05) than the AI (13 +/- 13) of Tc-99m ECD SPECT in patients with TLE. In NE, the sensitivity of Tc-99m HMPAO SPECT was 70% (16 of 23), but that of Tc-99m ECD SPECT was 29% (two of seven). The AI (15 +/- 10) of Tc-99m HMPAO SPECT was significantly larger (p = 0.02) than the AI (4.8 +/- 6) of Tc-99m ECD SPECT in patients with NE. Subtraction ictal SPECT coregistered to MR...Continue Reading

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Citations

May 21, 2003·Seminars in Nuclear Medicine·Thomas R Henry, Ronald L Van Heertum
Jul 26, 2011·International Journal of Molecular Imaging·Sunhee Kim, James M Mountz
Feb 26, 2014·Revista española de medicina nuclear e imagen molecular·X SetoainF Lomeña
Apr 15, 2011·International Journal of Molecular Imaging·Sita JayalakshmiManas Panigrahi
Oct 11, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Petros StylianouSagi Harnof
Jul 30, 2004·Epilepsia·W Van Paesschen
Aug 21, 2007·Seminars in Nuclear Medicine·Shekhar PatilLise Borgwardt
Jan 13, 2018·Frontiers in Veterinary Science·Marion Bankstahl, Jens P Bankstahl
Mar 25, 2020·Nuclear Medicine and Molecular Imaging·Teck Huat WongDong Soo Lee

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