Superovulation, IGFBP-1 and birth weight

European Journal of Obstetrics, Gynecology, and Reproductive Biology
M R JohnsonK H Nicolaides

Abstract

In this study, the effect of superovulation on the circulating levels of insulin-like growth factor binding protein-1 (IGFBP-1) has been investigated. IGFBP-1 levels were measured in singleton pregnancies achieved either naturally (n = 203) or following superovulation, in-vitro fertilisation and embryo transfer (IVF-ET) with either pituitary desensitisation with buserelin and superovulation with human menopausal gonadotrophin (b/hMG) followed by IVF-ET (n = 15) or with clomiphene citrate and hMG (CC/hMG) followed by IVF-ET (n = 15, 1st trimester only). The circulating levels of IGFBP-1 were similar in all three groups during the first trimester, and in both normal and b/hMG pregnancies in the second, but were significantly higher during the third trimester in b/hMG pregnancies than in normal pregnancies (P = 0.0002). The birth weights were significantly lower in the b/hMG group (P = 0.04), but not in the CC/hMG group compared with natural conceptions. Gestational age at delivery was similar in control and b/hMG pregnancies, but significantly reduced in CC/hMG pregnancies (P = 0.04). These data suggest that pregnancies achieved following superovulation with b/hMG are associated with elevated levels of IGFBP-1 during the third tr...Continue Reading

References

Jan 1, 1989·Acta Obstetricia Et Gynecologica Scandinavica·R J HowellT Chard
Feb 1, 1980·British Journal of Obstetrics and Gynaecology·D G Altman, E C Coles
Mar 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A A BrooksH I Abdalla
May 12, 1995·Early Human Development·A A BrooksH I Abdalla

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Citations

Oct 16, 2003·Placenta·I CetinP Antonazzo
Mar 8, 2002·The New England Journal of Medicine·Laura A SchieveLynne S Wilcox
Dec 25, 2012·Molecular Human Reproduction·S K FeuerP F Rinaudo
Feb 5, 2013·Fertility and Sterility·Laxmi A Kondapalli, Alfredo Perales-Puchalt
Mar 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tracy LightfootMichael Murphy
Mar 3, 2004·Obstetrics and Gynecology·Rebecca A JacksonMary S Croughan
Jul 5, 2005·Human Reproduction Update·Bernhard Horsthemke, Michael Ludwig
Feb 23, 2020·BMC Pregnancy and Childbirth·Shana Ginar da SilvaIná da Silva Dos Santos

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