Superoxide anion as a marker of ischemia-reperfusion injury of the transplanted kidney

Transplantation Proceedings
M MasztalerzJ Kedziora

Abstract

Reactive oxygen species (ROS) are considered to be important factors involved in the pathophysiology of renal ischemia-reperfusion injury. ROS-induced alterations of proteins, carbohydrates, DNA, and lipid membranes lead to cell and organ dysfunction. Several antioxidant defense mechanisms exist to prevent or limit oxidant injury. Cellular Cu-Zn superoxide dismutase, catalase, and cellular glutathione peroxidase (cGSH-Px) are enzyme ROS scavengers, implicated in the protection against kidney damage resulting from ischemia-reperfusion injury. Reduced glutathione, a cosubstrate of cGSH-Px, have been shown to display a reductive properties without the contribution of enzymes. We examined superoxide anion (O(2)(-)) production by neutrophils, without and with stimulation using opsonized zymosan, in the whole blood of renal transplant patients before and after (5 and 15 minutes) reperfusion. The mean O(2)(-) concentration after reperfusion was statistically significantly higher than that before reperfusion.

References

Feb 1, 1992·Journal of the American Society of Nephrology : JASN·M S Paller, M Patten
Jan 1, 1991·Free Radical Biology & Medicine·M S Paller
Nov 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S P Andreoli
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Oct 1, 1984·The Journal of Clinical Investigation·M S PallerT F Ferris
Aug 4, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M HeinzelmannJ C Passmore
Nov 1, 2000·Surgery·C F ZwemerC L Phillips
Oct 11, 2001·American Journal of Physiology. Renal Physiology·E NoiriM S Goligorsky

❮ Previous
Next ❯

Citations

Jul 16, 2011·Journal of Thyroid Research·Martha FrancoOscar Pérez-Méndez
Nov 27, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Prabal K Chatterjee
Mar 29, 2014·The Journal of Surgical Research·Min-Wen SuChen-Fuh Lam
Nov 13, 2007·Free Radical Biology & Medicine·Cheryl J MaenpaaVani Nilakantan
Apr 30, 2016·Indian Journal of Pharmacology·Shokofeh Banaei
Sep 14, 2011·Transplantation Proceedings·T CelicD Bobinac
Feb 5, 2014·Clinical and Experimental Nephrology·Nasser AhmadiaslEhsan Azimian
Jan 26, 2008·American Journal of Nephrology·Björn JüttnerDirk Scheinichen
Nov 18, 2011·Journal of Agricultural and Food Chemistry·Raymond YangKelly Anne Meckling
Jun 6, 2017·American Journal of Physiology. Renal Physiology·Jin WeiRuisheng Liu
Sep 25, 2018·Transplantation·Begoña García-CenadorFrancisco J López-Hernández
May 27, 2011·American Journal of Physiology. Renal Physiology·Norma B Ojeda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.