Superoxide anion-induced histamine release from rat peritoneal mast cells

Biological & Pharmaceutical Bulletin
M AkagiR Akagi

Abstract

We investigated the properties of superoxide anion (O2-)-induced histamine release from rat peritoneal mast cells using superoxide anion radicals obtained from potassium superoxide (KO2). KO2 elicited a rapid histamine release in a dose-dependent fashion, without lactate dehydrogenase (LDH) release. The KO2-induced release was temperature- and energy-dependent. KO2 rapidly increased the intracellular free Ca2+ concentration, accompanied by a marked increase of Ca(2+)-uptake. These findings indicate that the increase in intracellular Ca2+ concentration is involved in the initiation of KO2-induced histamine release, and KO2 could be used as an agent of O2(-)-induced biological reactions.

Citations

Aug 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kei ShimodaHiroki Hamada
Sep 2, 2000·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R KanohM Akagi
Jul 14, 2010·International Immunopharmacology·Hui-Di QinZhao-Ping Liu
Mar 19, 2016·Canadian Journal of Physiology and Pharmacology·Honghua JinPengyuan Sun
Jul 22, 2017·Annals of the New York Academy of Sciences·Daniel M GrochowskiMichał Tomczyk
Jan 27, 2011·Anatomy & Cell Biology·Yun Ho ChoiChang Ho Song
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Yun Ho ChoiChang Ho Song
Aug 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuya FujitakaTomohiro Saikawa

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