Superoxide dismustase mimetic tempol decreases blood pressure by increasing renal medullary blood flow in hyperinsulinemic-hypertensive rats

Metabolism: Clinical and Experimental
Shizuka Onuma, Kazushige Nakanishi

Abstract

Insulin resistance and compensatory hyperinsulinemia often coexist in hypertensive patients, which may play a role in the development of hypertension. Because medullary blood flow (MBF), which is strongly influenced by the nitric oxide (NO) system, is thought to be an important component of blood pressure and sodium balance, we focused particularly on MBF in fructose-induced hypertensive rats. Moreover, it has been reported that the increased reactive oxygen species (ROS) in the kidney may contribute to the development of hypertension. Our study was thus designed to test the hypotheses that MBF is diminished in fructose-hypertensive rats (FFR) and that administration of tempol, a membrane-permeable mimetic of superoxide dismutase (SOD), decreases mean arterial pressure (MAP) by increasing MBF. Male Sprague-Dawley rats (180 to 200 g) were divided into 6 groups: control untreated (C, n = 5), control tempol-treated (in drinking water) (CT, n = 4), control L-arginine-treated (in drinking water) (CA, n = 6), fructose-fed untreated (F, n = 7), fructose-fed tempol-treated (FT, n = 7), and fructose-fed L-arginine-treated rats (in drinking water) (FA, n = 6). MAP and 24-hour urine samples were measured weekly over a 4-week test period. ...Continue Reading

References

Nov 1, 1987·Hypertension·I S HwangG M Reaven
Apr 1, 1995·Hypertension·A W CowleyR J Roman
Jun 18, 1999·Hypertension·K FujiwaraT Saruta
Mar 7, 2001·Hypertension·L O LermanJ C Romero
Mar 7, 2001·Hypertension·A P ZouA W Cowley
Jan 31, 2002·Journal of Endocrinological Investigation·A CavarapeA Ceriello
May 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allen W CowleyAi-Ping Zou
Jun 5, 2003·Hypertension·Ayako MakinoAllen W Cowley

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Citations

Dec 30, 2008·Pharmacological Reviews·Christopher S Wilcox, Adam Pearlman
Aug 13, 2010·American Journal of Physiology. Renal Physiology·Chunhua CaoThomas L Pallone
Jul 26, 2011·International Journal of Nephrology·Mohammed H AbdullaEdward J Johns
Aug 31, 2011·Journal of Nutrition and Metabolism·Marcela Alejandra Vazquez-PrietoRoberto Miguel Miatello
Nov 8, 2014·Journal of Hypertension·Waleska C DornasMarcelo E Silva
Jan 11, 2013·American Journal of Physiology. Renal Physiology·Edilia TapiaLaura-Gabriela Sánchez-Lozada
Jul 3, 2013·Physiology·Alfonso Eirin, Lilach O Lerman
Jan 21, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mohammed H AbdullaEdward J Johns
Mar 10, 2009·Pharmacology & Therapeutics·Ulf SimonsenNiels Henrik Buus
Sep 18, 2008·Angiology·Selvaraj NambiarSridhar Gopalakrishna Magadi
Jun 29, 2017·American Journal of Physiology. Endocrinology and Metabolism·Nathan C WinnJaume Padilla
May 11, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ning ZhangFeng Zhao
Sep 24, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yanny E LauGregory D Fink
Jun 14, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Olga P Romanko, David W Stepp
Jan 23, 2021·Antioxidants·Yu Ah Hong, Cheol Whee Park

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