Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic.

Angewandte Chemie
Benjamin G TristKay L Double

Abstract

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide breakdown and is important for most forms of eukaryotic life. The evolution of aerobic respiration by mitochondria increased cellular production of superoxide, resulting in an increased reliance upon SOD1. Consistent with the importance of SOD1 for cellular health, many human diseases of the central nervous system involve perturbations in SOD1 biology. But far from providing a simple demonstration of how disease arises from SOD1 loss-of-function, attempts to elucidate pathways by which atypical SOD1 biology leads to neurodegeneration have revealed unexpectedly complex molecular characteristics delineating healthy, functional SOD1 protein from that which likely contributes to central nervous system disease. This review summarises current understanding of SOD1 biology from SOD1 genetics through to protein function and stability.

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Citations

Dec 18, 2020·Frontiers in Cellular Neuroscience·Luke McAlaryNeil R Cashman
May 22, 2021·Chemical Reviews·Philip A DobleDavid Clases
Apr 21, 2021·Angewandte Chemie·Katelyn M BaumerBryan F Shaw
Jun 15, 2021·Chemical Science·Sian GenoudKay L Double
Aug 20, 2020·Translational Neurodegeneration·Yoshiaki Furukawa, Eiichi Tokuda

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