Superoxide dismutase activity and gene expression levels in Saudi women with recurrent miscarriage

Molecular Medicine Reports
Hazem K GhneimMourad A M Aboul-Soud

Abstract

The antioxidant activities of superoxide dismutase 1 (SOD1) and SOD2, as well as the levels of the oxidant superoxide anion (SOA) and the micronutrients zinc (Zn), copper (Cu) and manganese (Mn), were assayed in plasma, whole blood and placental tissue of non‑pregnant (NP), healthy pregnant (HP) women and recurrent miscarriage (RM) patients. The results showed that SOD1 and SOD2 activities and the levels of Zn, Cu and Mn in plasma and whole blood of HP women were slightly, but significantly lower, and even more significantly decreased in RM patients compared to those observed in NP women (P<0.05 and P<0.0001, respectively). Additionally, whereas plasma SOD1 and SOD2 activities and Zn, Cu and Mn levels were significantly lower in RM patients, those of whole blood and placental tissue were significantly lower when compared to HP women (P<0.001 and P<0.0001, respectively). Concurrently, there were consistent increases of equal magnitude and statistical significance in SOA levels in all the assayed samples as identified by a comparison between the subjects. The findings thus supported oxidative metabolism and excessive reactive oxygen species generation. The resultant oxidative stress, identified in whole blood and placental tissue...Continue Reading

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Citations

Aug 24, 2018·Biology of Reproduction·Hamid-Reza Kohan-GhadrSascha Drewlo
May 19, 2018·International Journal of Molecular Sciences·Rajaa AouacheFrancisco Miralles
Jul 5, 2017·Experimental and Therapeutic Medicine·Yazeed A Al-SheikhMourad A M Aboul-Soud
Nov 28, 2019·Experimental and Therapeutic Medicine·Yazeed A Al-SheikhMourad A M Aboul-Soud
Aug 17, 2021·Frontiers in Medicine·Nourah H Al QahtaniJ Francis Borgio

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Methods Mentioned

BETA
protein folding
RNA assay
Assay

Software Mentioned

Rotor
Gene cycler

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