PMID: 9539407Apr 16, 1998Paper

Superoxide dismutase activity in cerebrospinal fluid of patients with dementia and some other neurological disorders

Alzheimer Disease and Associated Disorders
P P De DeynA Mori

Abstract

Data on superoxide dismutase (SOD) activity in the cerebrospinal fluid (CSF) of patients suffering from dementia (n=32) as compared with a control group (n=58), a Parkinson disease (PD) patient group (n=12), and a group of individuals suffering from epilepsy (n=13) are presented. SOD activity was determined by electron spin resonance spectrometry using the spin trap method. No significant correlation was found between CSF SOD activity and age in the control group. In addition, CSF SOD activity was not gender dependent. One-way analysis of variance showed a highly significant between-groups effect for the CSF SOD activity and specific CSF SOD activity of the four major groups (p=0.0008). Post hoc comparison (Fisher PLSD test) revealed significant differences between the control group and the total dementia group (p < 0.001), between the dementia group and the epilepsy group (p < 0.01), and between the dementia group and the PD group (p < 0.05). The CSF of patients with PD or epilepsy showed a similar SOD activity as the CSF of control patients. In addition, CSF SOD activity levels were significantly lower in the total dementia group (p=0.002) and in the group with dementia of the Alzheimer type (DAT) (p=0.001) than in the dement...Continue Reading

Citations

Dec 21, 2000·Experimental Gerontology·O ToussaintJ Vanfleteren
Dec 1, 2006·Cognitive Neuropsychology·Emmanuel J BarbeauMichel Poncet
May 5, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Brit Mollenhauer, Claudia Trenkwalder
Nov 30, 2011·Journal of Neurochemistry·Blaine R RobertsJames A Duce
Nov 9, 2010·Analytica Chimica Acta·Bernhard Michalke, Volker Nischwitz
Dec 16, 2005·Redox Report : Communications in Free Radical Research·Aleksandra Nikolić KokićMihajlo B Spasić
May 11, 2010·Neurobiology of Disease·Karin D van DijkWilma D J van de Berg
Nov 27, 2014·Frontiers in Cellular Neuroscience·Félix J Jiménez-JiménezJosé A G Agúndez

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