Superoxide dismutase activity in cisternal cerebrospinal fluid after aneurysmal subarachnoid haemorrhage

Acta neurochirurgica
P GaetaniF Marzatico

Abstract

It has been recognised that the level of superoxide dismutase (SOD) significantly increases in CSF as the result of cerebral ischaemic damage. The aim of this study was to correlate the CSF levels of SOD enzymatic activity to the patterns of subarachnoid haemorrhage with regards to ischaemic complications due to vasospasm. A series of 78 patients operated on for intracranial aneurysms was studied; all patients were monitored with serial TCD measurements every second day after SAH. CSF samples were obtained at surgery by cisternal puncture of the subarachnoid cistern nearest to the aneurysm. SOD activity was assayed spectrophotometrically. Mean cisternal CSF level of SOD in 12 control cases (12.99 +/- 2.33 U/ml) is significantly higher (p < 0.01) than in 26 patients operated on between day 1 and 3 from last SAH episode (4.44 +/- 0.7 U/ml) and in 40 patients treated by delayed surgery (7.64 +/- 0.92 U/ml). In 13 patients presenting neurological deterioration related to arterial vasospasm mean cisternal SOD level was 12.23 +/- 1.86 U/ml; in 27 cases without vasospasm mean level was 5.43 +/- 0.7 U/ml (p < 001). The present results suggest that (a) cisternal CSF levels of SOD significantly decreases after SAH, probably in relation t...Continue Reading

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Citations

Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Alexander Y. ZubkovJohn H. Zhang
Nov 17, 1998·Journal of Neurosurgery·P GaetaniF Marzatico
Mar 15, 2012·Progress in Neurobiology·Fatima A SehbaJohn H Zhang
Mar 3, 2009·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Luigi A L Lanterna, F Biroli
Sep 25, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Jun Zhang, Richard E Claterbuck
Oct 1, 2013·Progress in Neurobiology·Sheng ChenJohn H Zhang
Oct 25, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Carl MuroiE Keller
Mar 17, 2000·Neurosurgery·H H Dietrich, R G Dacey

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