PMID: 8980931Dec 1, 1996Paper

Superoxide dismutase activity in duodenal ulcer patients

European Journal of Gastroenterology & Hepatology
E KlinowskiE Scapa

Abstract

To investigate whether duodenal ulcer (DU) is associated with increased free radical generation at the site of ulceration and to attempt, indirectly, to confirm the hypothesis by determining activity of free radical scavengers such as superoxide dismutase (SOD). Prospective study comparing SOD activity in biopsies taken from the ulcer edge, and antrum in DU patients before and after one month of treatment to SOD activity in biopsies from the duodenal bulb and antrum in a control population. Institute of Gastroenterology of a university hospital. Twenty-five patients with DU. The diagnosis was confirmed by endoscopy. SOD activity in biopsy specimen, red blood cells (RBC) and serum was measured using the cytochrome c method by spectrophotometry and expressed as U SOD/mg protein. Helicobacter pylori was diagnosed by the rapid urease test (CLO test) from antral biopsies. SOD activity was markedly depleted in the ulcer edge (2.78 +/- 0.9 U SOD/mg protein) as compared to the same patients after one month of treatment (4.59 +/- 2.2 U SOD/mg protein) (P = 0.05) and to biopsies from the duodenal bulb in control population (6.7 +/- 2.4 U.SOD/mg protein) (P = 0.05). SOD activity in the antrum of both groups was similar. There was no diffe...Continue Reading

Citations

Apr 4, 2007·Digestive Diseases and Sciences·Cuong D TranErin L Symonds
Dec 16, 2011·European Journal of Pharmacology·Fernanda GumilarOscar Quinzani
Feb 18, 2004·World Journal of Gastroenterology : WJG·Jane C J ChaoChia-Lang Fang
Apr 10, 2002·Pathology International·Kenji NoguchiHironobu Sasano
Apr 3, 2014·Physiological Reviews·Asima BhattacharyyaSheila E Crowe
Nov 18, 2018·Nature Reviews. Gastroenterology & Hepatology·Eric L Campbell, Sean P Colgan
Jul 20, 2006·Journal of the American Chemical Society·Christopher E JonesGraeme R Hanson

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