Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage

PloS One
Masato KoikeKazuo Kaneko

Abstract

Recent studies have shown that superoxide dismutase 1 (SOD1), SOD2, and SOD3 are significantly decreased in human osteoarthritic cartilage. SOD activity is a marker that can be used to comprehensively evaluate the enzymatic capacities of SOD1, SOD2, and SOD3; however, the trend of SOD activity in end-stage osteoarthritic tissues remains unknown. In the present study, we found that SOD activity in end-stage osteoarthritic synovium of the knee was significantly lower than that in control synovium without the influence of age. The SOD activity was significantly lower in the end-stage knee osteoarthritic cartilage than in the control, but a weak negative correlation was observed between aging and SOD activity. However, SOD activity in end-stage hip osteoarthritic cartilage was significantly lower than that in control cartilage without the influence of aging. The relationship between osteoarthritis and SOD activity was stronger than the relationship between aging and SOD activity. These results indicate that direct regulation of SOD activity in joint tissues may lead to suppression of osteoarthritis progression.

References

Jan 16, 1999·Free Radical Biology & Medicine·L L de ZwartN P Vermeulen
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Oct 29, 2005·Arthritis and Rheumatism·Elizabeth ReganJames Crapo
Jun 26, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Valéry AfonsoAbderrahim Lomri
Jan 1, 2008·Arthritis and Rheumatism·Reva C LawrenceUNKNOWN National Arthritis Data Workgroup
Oct 20, 2009·Biochimica Et Biophysica Acta·Fumiyuki Yamakura, Hiroaki Kawasaki
Feb 5, 2010·Best Practice & Research. Clinical Rheumatology·A Shane Anderson, Richard F Loeser
Jun 1, 2010·Annals of the Rheumatic Diseases·Jenny L ScottDavid A Young
Jun 29, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Liying JiangYashuang Zhao
Mar 15, 2011·Osteoarthritis and Cartilage·V B KrausUNKNOWN OARSI FDA Osteoarthritis Biomarkers Working Group
Aug 30, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Katherine J WolffJames A Martin
Feb 26, 2013·Free Radical Biology & Medicine·Stefan I Liochev
Jan 7, 2015·Archives of Biochemistry and Biophysics·Yiqiang ZhangAdam B Salmon
Jan 16, 2016·Biochimica Et Biophysica Acta·Panagiotis Lepetsos, Athanasios G Papavassiliou
May 20, 2016·Nature Reviews. Rheumatology·Richard F LoeserBrian O Diekman
Jun 15, 2016·Annals of the Rheumatic Diseases·Virginia Byers KrausUNKNOWN OA Biomarkers Consortium

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Citations

Sep 15, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Keiichi YoshidaKazuo Kaneko
Feb 7, 2021·Medical Hypotheses·Sandra Caramujo-BalseiroLina Carvalho
May 21, 2021·The American Journal of Sports Medicine·Yoshiaki ItoigawaMuneaki Ishijima
Jul 3, 2021·Antioxidants·Nicoleta Bianca TudorachiElena Mihaela Cărăuşu
Jun 30, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hirohisa UeharaMuneaki Ishijima

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Methods Mentioned

BETA
biopsy
Assay
Protein Assay
total hip arthroplasty
MDA
acetylation

Software Mentioned

ImageJ
NIS
Elements F
SPSS Statistics

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