PMID: 421692Feb 8, 1979Paper

Superoxide dismutase and glutathione peroxidase in polymorphonuclear leucocytes

European Journal of Pediatrics
M RisterE Gladtke

Abstract

Superoxide dismutase (SOD) and glutathione peroxidase (GPX) protect aerobic organisms against the toxic superoxide anion and hydrogen peroxide, which are generated during phagocytosis by polymorphonuclear leucocytes (PMNs). PMNs of children with bacterial infections and with infectious hepatitis contained significantly elevated SOD activity, whereas GPX activity remained in the normal range. In contrast, PMNs of children with viral infections and rheumatoid arthritis exhibited a decreased SOD activity, while GPX activity was again unchanged. The children's age, sex or treatment did not effect the enzyme activities in PMNs. Since SOD generates bactericidal hydrogen peroxide and regulates the release of the toxic superoxide radical into the surrounding tissues, this study may add new understanding to the pathophysiological aspects of acute and chronic inflammatory processes.

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Citations

Dec 1, 1980·European Journal of Pediatrics·M RisterE Gladtke
Jan 1, 1988·Free Radical Biology & Medicine·P BiemondJ F Koster
Jul 1, 1982·Agents and Actions·J R SorensonT M Rolniak
Jan 1, 1984·Medical Hypotheses·M McCarty
Jan 1, 1987·CRC Critical Reviews in Biochemistry·J V BannisterG Rotilio
Dec 1, 1999·Nutrition Research Reviews·R J Maughan
Jun 1, 1982·Klinische Wochenschrift·M Rister, K Bauermeister
Aug 15, 1985·Biochemical Pharmacology·A M Mann, F J Darby
Jan 1, 1993·Progress in Histochemistry and Cytochemistry·D Dayan, M Wolman

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