PMID: 421692Feb 8, 1979Paper

Superoxide dismutase and glutathione peroxidase in polymorphonuclear leucocytes

European Journal of Pediatrics
M RisterE Gladtke


Superoxide dismutase (SOD) and glutathione peroxidase (GPX) protect aerobic organisms against the toxic superoxide anion and hydrogen peroxide, which are generated during phagocytosis by polymorphonuclear leucocytes (PMNs). PMNs of children with bacterial infections and with infectious hepatitis contained significantly elevated SOD activity, whereas GPX activity remained in the normal range. In contrast, PMNs of children with viral infections and rheumatoid arthritis exhibited a decreased SOD activity, while GPX activity was again unchanged. The children's age, sex or treatment did not effect the enzyme activities in PMNs. Since SOD generates bactericidal hydrogen peroxide and regulates the release of the toxic superoxide radical into the surrounding tissues, this study may add new understanding to the pathophysiological aspects of acute and chronic inflammatory processes.


Mar 23, 1978·The New England Journal of Medicine·B M Babior
Sep 1, 1975·The Journal of Clinical Investigation·R L BaehnerR B Johnston
Dec 1, 1975·The American Journal of Medicine·R D Fairshter, A F Wilson
Apr 1, 1976·The Journal of Clinical Investigation·R B Johnston, J E Lehmeyer
May 1, 1976·Annals of Clinical Biochemistry·J M Gutteridge
Feb 1, 1977·The Journal of Clinical Investigation·I M GoldsteinH B Kaplan
Aug 1, 1977·The Journal of Clinical Investigation·S J WeissA F LoBuglio
Jun 9, 1978·Deutsche medizinische Wochenschrift·M Rister, R L Baehner
Oct 1, 1976·Archives of Biochemistry and Biophysics·H Misra, I Fridovich
Aug 1, 1977·The Journal of Clinical Investigation·A I Tauber, B M Babior
May 17, 1976·Biochemical and Biophysical Research Communications·A PetkauC Barefoot
Jan 1, 1975·Annual Review of Biochemistry·I Fridovich
Aug 4, 1975·Biochemical and Biophysical Research Communications·A PetkauC M Brady
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Sep 1, 1975·Mechanisms of Ageing and Development·C StevensJ C Freedman
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May 1, 1973·Journal of Bacteriology·E M Gregory, I Fridovich
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Mar 1, 1973·The Journal of Clinical Investigation·B M BabiorJ T Curnutte
Jul 30, 1970·The New England Journal of Medicine·B HolmesR A Good
Aug 1, 1974·FEBS Letters·P PatriarcaF Rossi
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Jul 12, 1973·Biochimica Et Biophysica Acta·C O Beauchamp, I Fridovich
Apr 1, 1974·The Journal of Clinical Investigation·L R DeChateletR B Johnston
Apr 1, 1974·Life Sciences·A P Autor
Jun 1, 1974·The American Journal of Physiology·J D Crapo, D F Tierney
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Dec 1, 1980·European Journal of Pediatrics·M RisterE Gladtke
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