Superoxide dismutases in chronic gastritis

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Dražen ŠvageljIvan Švagelj

Abstract

Human gastric diseases have shown significant changes in the activity and expression of superoxide dismutase (SOD) isoforms. The aim of this study was to detect Mn-SOD activity and expression in the tissue of gastric mucosa, primarily in chronic gastritis (immunohistochemical Helicobacter pylori-negative gastritis, without other pathohistological changes) and to evaluate their possible connection with pathohistological diagnosis. We examined 51 consecutive outpatients undergoing endoscopy for upper gastrointestinal symptoms. Patients were classified based on their histopathological examinations and divided into three groups: 51 patients (archive samples between 2004-2009) with chronic immunohistochemical Helicobacter pylori-negative gastritis (mononuclear cells infiltration were graded as absent, moderate, severe) divided into three groups. Severity of gastritis was graded according to the updated Sydney system. Gastric tissue samples were used to determine the expression of Mn-SOD with anti-Mn-SOD Ab immunohistochemically. The Mn-SOD expression was more frequently present in specimens with severe and moderate inflammation of gastric mucosa than in those with normal mucosa. In patients with normal histological finding, positive...Continue Reading

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·B N AmesW C Willett
Aug 9, 2001·Antioxidants & Redox Signaling·L W Oberley
Apr 10, 2002·Pathology International·Kenji NoguchiHironobu Sasano
Jul 20, 2002·Free Radical Biology & Medicine·Yuji Naito, Toshikazu Yoshikawa
Mar 11, 2003·Redox Report : Communications in Free Radical Research·Futoshi Okada
Sep 2, 2003·The Journal of Pathology·Laurens KruidenierHein W Verspaget
May 12, 2004·Current Medicinal Chemistry·Giovambattista PaniTommaso Galeotti
Jul 23, 2005·World Journal of Gastroenterology : WJG·Shao-Hong WangXiao-Yang Qiu
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
Oct 24, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M MonariV Tugnoli
Nov 30, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T S HwangH S Han
Dec 17, 2008·Current Medicinal Chemistry·Werner Hoffmann
Feb 4, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Taro IkumotoJohji Imura

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Citations

Nov 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ting WangGuangrui Huang

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