PMID: 9541643Apr 29, 1998Paper

Superoxide formation and DNA damage induced by a fragrant furanone in the presence of copper(II)

Mutation Research
N YamashitaShosuke Kawanishi

Abstract

2,5-Dimethyl-4-hydroxy-3(2H)-furanone (2,5-DMHF), a caramel-like fragrant compound found in may processed foodstuff, has been reported to be mutagenic. 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (4,5-DMHF), which is a similar characteristic fragrant compound, has no report concerning its mutagenicity. DNA damage by 2,5-DMHF and 4,5-DMHF was investigated by using DNA fragments obtained from the p53 tumor suppressor gene. 2,5-DMHF induced DNA damage extensively in the presence of Cu(II), but only slightly in the presence of Fe(III). 4,5-DMHF did not cause metal-dependent DNA damage. Bathocuproine, a Cu(I)-specific chelator, and catalase inhibited DNA damage induced by 2,5-DMHF plus Cu(II), whereas free hydroxyl radical scavengers did not. The order of DNA cleavage sites was thymine, cytosine > guanine residues. The site-specific DNA damage and effects of scavengers show that DNA-copper-oxygen complex rather than free .OH are involved in the DNA damage. Formation of 8-oxodeoxyguanosine (8-oxodG) by 2,5-DMHF increased with its concentration in the presence of Cu(II), whereas 8-oxodG formation increased only slightly in the presence of Fe(III). Degradation of 2,5-DMHF was efficiently accelerated by Cu(II), but only slightly accelerated b...Continue Reading

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Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·Y HirakuS Kawanishi
Nov 24, 1999·Archives of Biochemistry and Biophysics·Y OhkumaS Kawanishi
Jun 25, 2005·Biochemical and Biophysical Research Communications·Kaoru MidorikawaShosuke Kawanishi
Feb 8, 2003·Archives of Biochemistry and Biophysics·Kazutaka HirakawaShosuke Kawanishi
Aug 2, 2003·Archives of Biochemistry and Biophysics·Takuya IwamotoShosuke Kawanishi
May 3, 2003·Biochemical and Biophysical Research Communications·Chitose TodaShosuke Kawanishi
Oct 18, 2003·Biochemical Pharmacology·Ayako FurukawaShosuke Kawanishi
Mar 23, 1999·Biochemical Pharmacology·M MurataS Kawanishi
Mar 20, 1999·Mutation Research·N YamashitaS Kawanishi
May 1, 1998·Cancer Letters·F ChenS Kawanishi
Apr 8, 2000·Free Radical Biology & Medicine·M MurataS Kawanishi
Mar 29, 2001·Free Radical Biology & Medicine·M MurataS Kawanishi
Sep 5, 2002·Free Radical Biology & Medicine·Katsuhisa SakanoShosuke Kawanishi
Sep 19, 1998·Free Radical Biology & Medicine·M MurataS Kawanishi
Apr 6, 2002·Current Opinion in Microbiology·Klaus WinzerPaul Williams
Sep 2, 2003·Mutation Research·Kazuhiko OgawaShosuke Kawanishi
Nov 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hideki Mizutani
Oct 26, 2001·Biochemical and Biophysical Research Communications·K MidorikawaS Kawanishi
Jan 12, 2002·Biochemical and Biophysical Research Communications·Shiho Ohnishi, Shosuke Kawanishi
Feb 13, 2001·Biochemical and Biophysical Research Communications·S OhnishiS Kawanishi
May 6, 2014·Biochimica Et Biophysica Acta·Yusuke HirakuMariko Murata
Nov 5, 1999·Free Radical Research·Y Hiraku, S Kawanishi
May 8, 2000·Free Radical Research·S OhnishiS Kawanishi
Jun 15, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wilfried Schwab
Dec 23, 2008·Mutation Research·Shinji OikawaShosuke Kawanishi
Jun 1, 2007·Journal of Photochemistry and Photobiology. B, Biology·Kazutaka HirakawaHiroshi Segawa
Feb 24, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K MurakamiM Yoshino
Dec 4, 2004·Mutation Research·Katsuhisa SakanoShosuke Kawanishi
Sep 11, 2004·Chemico-biological Interactions·Katsuhisa SakanoShosuke Kawanishi
Aug 12, 2004·Free Radical Biology & Medicine·Mariko MurataShosuke Kawanishi
Mar 21, 2006·Free Radical Biology & Medicine·Mariko MurataShosuke Kawanishi
Oct 19, 2005·Journal of Photochemistry and Photobiology. B, Biology·Kazutaka HirakawaMasahide Yasuda
Oct 4, 2005·Free Radical Biology & Medicine·Katsuhisa SakanoShosuke Kawanishi

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