PMID: 16514172Mar 4, 2006Paper

Superoxide formation and interaction with nitric oxide modulate systemic arterial pressure and renal function in salt-depleted dogs

Experimental Biology and Medicine
Utpal K DuttaD S Majid

Abstract

To determine the role of superoxide (O(2)(-)) formation in the kidney during alterations in the renin-angiotensin system, we evaluated responses to the intra-arterial infusion of an O(2)(-) - scavenging agent, tempol, in the denervated kidney of anesthetized salt-depleted (SD, n=6) dogs and salt-replete (SR, n=6) dogs. As expected, basal plasma renin activity was higher in SD than in SR dogs (8.4 +/- 1.0 vs. 2.3 +/- 0.6 ng angiotensin 1/ml/hr). Interestingly, the basal level of urinary F(2)-isoprostanes excretion (marker for endogenous O(2)(-) activity) relative to creatinine (Cr) excretion was also significantly higher in SD compared to SR dogs (9.1 +/- 2.8 vs. 1.6 +/- 0.4 ng F(2)-isoprostanes/mg of Cr). There was a significant increase in renal blood flow (4.3 +/- 0.5 to 4.9 +/- 0.6 ml/min/g) and decreases in renal vascular resistance (38.2 +/- 5.8 to 33.2 +/- 4.7 mm Hg/ml/min/g) and mean systemic arterial pressure (148 +/- 6 to 112 +/- 10 mm Hg) in SD dogs but not in SR dogs during infusion of tempol at 1 mg/kg/min for 30 mins. Glomerular filtration rate and urinary sodium excretion (U(Na)V) did not change significantly during tempol infusion in both groups of dogs. Administration of the nitric oxide synthase inhibitor nitro...Continue Reading

References

Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
May 1, 1991·The Journal of Clinical Investigation·A SamuniA Russo
Mar 20, 1990·Biochemistry·J B MitchellA Russo
May 15, 1995·FEBS Letters·H Ischiropoulos, A B al-Mehdi
May 25, 1995·Biochemical and Biophysical Research Communications·M G SalgoW A Pryor
May 1, 1993·Biochemical Society Transactions·J S Beckman, J P Crow
Jul 15, 1997·The Journal of Clinical Investigation·H M Siragy, R M Carey
Dec 24, 1997·Journal of the Autonomic Nervous System·S B Jou, J T Cheng
Sep 12, 1998·Kidney International·E A JaimesL Raij
Mar 17, 2000·Free Radical Biology & Medicine·L J Roberts, J D Morrow
Sep 1, 2000·Regulatory Peptides·K K Griendling, M Ushio-Fukai
Mar 7, 2001·Hypertension·A P ZouA W Cowley
Jun 20, 2001·American Journal of Hypertension·D S Majid, L G Navar
Feb 16, 2002·Hypertension·Dewan S A Majid, Akira Nishiyama
Mar 9, 2002·Current Hypertension Reports·Christopher S Wilcox
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Pablo A Ortiz, Jeffrey L Garvin
Feb 8, 2003·Hypertension·Takatomi ShokojiYouichi Abe
Feb 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Caroline RugaleBernard Jover
Apr 30, 2003·Hypertension·Shumei MengR Davis Manning
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Chagriya KitiyakaraChristopher S Wilcox
Oct 30, 2003·Free Radical Biology & Medicine·Laine J MurpheyNancy J Brown
Jan 13, 2004·Journal of Applied Physiology·B D NossamanP J Kadowitz
Mar 6, 2004·American Journal of Physiology. Renal Physiology·Bernardo Rodríguez-IturbeRichard J Johnson
Mar 27, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dewan S A MajidAlexander Castillo
Jul 13, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrew J GowHarry Ischiropoulos
Oct 7, 2004·American Journal of Physiology. Renal Physiology·Dewan S A MajidAlexander Castillo

❮ Previous
Next ❯

Citations

Jul 4, 2008·American Journal of Physiology. Renal Physiology·Mohammed Z Haque, Dewan S A Majid
Mar 13, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Carl SofflerDiana M Hassel
Sep 9, 2011·American Journal of Physiology. Renal Physiology·Lucienne S LaraMinolfa C Prieto
Jan 25, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juan Manuel MorenoFélix Vargas
Nov 7, 2008·American Journal of Physiology. Renal Physiology·Luis C MatavelliDewan S A Majid
Jan 21, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mohammed H AbdullaEdward J Johns
Jun 8, 2012·American Journal of Physiology. Renal Physiology·Wararat KittikulsuthDavid M Pollock
Dec 30, 2008·Pharmacological Reviews·Christopher S Wilcox, Adam Pearlman
Apr 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·Rocío Perez-AbudFélix Vargas
Nov 21, 2014·American Journal of Physiology. Renal Physiology·Catherina A CuevasMinolfa C Prieto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.