PMID: 804030Jan 1, 1975Paper

Superoxide production by phagocytic leukocytes

The Journal of Experimental Medicine
D B Drath, M L Karnovsky

Abstract

Mononuclear phagocytic leukocytes, as well as polymorphonuclear leukocytes, produce and release superoxide at rest, and this is stimulated by phagocytosis. Of the mouse monocytic cells studied, alveolar macrophages released the largest amounts of superoxide during phagocytosis, followed by normal peritoneal macrophages. Casein-elicited and "activated" macrophages released smaller quantities. In the guinea pig, polymorphonuclear leukocytes and casein-elicited macrophages were shown to release superoxide during phagocytosis whereas alveolar macrophages did not. Superoxide release accounted for only a small fraction of the respiratory burst of phagocytosis in all but the normal mouse peritoneal macrophage, the guinea pig polymorphonuclear leukocyte, and probably the mouse alveolar macrophage. There are obviously considerable species differences in O2-release by various leukocytes that might reflect both the production and/or destruction (e.g. by dismutase) of that substance.

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Jul 1, 1973·The Journal of Experimental Medicine·S R Simmons, M L Karnovsky
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Citations

Jul 1, 1979·Inflammation·D B DrathG L Huber
Mar 30, 1994·Molecular and Cellular Biochemistry·K C Das, H P Misra
Feb 1, 1976·Agents and Actions·F RossiP Patriarca
Jan 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R J HelmkeJ A Mangos
Nov 25, 1983·Journal of Immunological Methods·M BarakD Merzbach
Jan 1, 1977·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·L M SimonE D Robin
Jan 1, 1988·Free Radical Biology & Medicine·P Bellavite
Jan 1, 1990·Free Radical Biology & Medicine·P J Barnes
Nov 21, 1998·Journal of Hepatology·A GabrielC R Gandhi
Jan 1, 1988·Experimental Pathology·L S Chyczewski, S L Sulkowski
Jun 28, 2002·Free Radical Biology & Medicine·Jan SandströmStefan L Marklund
Jul 1, 1997·British Journal of Pharmacology·V BauerY Ito
Mar 23, 1978·The New England Journal of Medicine·B M Babior
Sep 13, 1979·The New England Journal of Medicine·W G Hocking, D W Golde
Oct 23, 1980·The New England Journal of Medicine·E R Unanue
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·L M CarlssonS L Marklund
Jul 1, 1978·The Journal of Experimental Medicine·R B JohnstonZ A Cohn
Oct 1, 1982·The Journal of Experimental Medicine·A Szuro-Sudol, C F Nathan
Feb 1, 1984·The Journal of Experimental Medicine·K Yamamoto, R B Johnston
Nov 1, 1987·Annals of Surgery·P T RoughneenB J Rowlands
Feb 1, 1996·American Journal of Reproductive Immunology : AJRI·T C ChaoR J Walter
Jan 1, 1986·Annals of the Rheumatic Diseases·C J MorrisM M Steven
Apr 1, 1993·American Journal of Respiratory Cell and Molecular Biology·Y RojanasakulJ K Ma
Nov 1, 1975·The Journal of Clinical Investigation·I M GoldsteinG Weissmann
May 11, 1976·The Journal of Clinical Investigation·A L SagoneE N Metz
Jan 1, 1978·The Journal of Clinical Investigation·W R Henderson, M Kaliner

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