Superoxide scavenging in the rostral ventrolateral medulla blunts the pressor response to peripheral chemoreflex activation

Brain Research
Fabiola C NunesValdir A Braga

Abstract

Peripheral chemoreflex activation has been considered the key drive for the overactivity of the sympathetic nervous system observed in some pathological conditions such as sleep obstructive apnea. In addition, increases in angiotensin-II-derived reactive oxygen species found in some autonomic regulatory brain areas have been implicated in hypertension. However, a link between oxidative stress and peripheral chemoreflex integration within the RVLM has never been investigated. Here, we tested the hypothesis that the pressor response induced by peripheral chemoreflex activation involves the angiotensin-II/AT(1)R/superoxide pathway within the rostral ventrolateral medulla (RVLM). Seventeen male Wistar rats (260-300 g) were implanted with bilateral guide cannulae towards the RVLM and were fitted with catheters for blood pressure recordings and drug administration. Peripheral chemoreflex activation with potassium cyanide (80 microg/kg, i.v.) produced a transient increase in blood pressure, which was attenuated 2 minutes after bilateral microinjection of losartan (1 nmol), an AT(1) receptor antagonist, in the RVLM (+54+/-4 vs +19+/-3 Delta mmHg, P<0.05, n=6). Moreover, superoxide scavenging in the RVLM using a superoxide dismutase (SO...Continue Reading

References

Jan 1, 1993·Journal of the Autonomic Nervous System·K G Franchini, E M Krieger
Mar 15, 1996·The Journal of Physiology·N Koshiya, P G Guyenet
Jun 1, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T TagawaR A Dampney
Aug 30, 2000·Respiration Physiology·P G Guyenet
Jul 19, 2001·Annals of the New York Academy of Sciences·G A Head, D N Mayorov
Jul 23, 2002·Autonomic Neuroscience : Basic & Clinical·Renata C H BarrosBenedito H Machado
Nov 29, 2002·Circulation Research·Matthew C ZimmermanRobin L Davisson
May 2, 2003·Current Hypertension Reports·Alan F SvedJudith C Sved
Feb 11, 2004·Progress in Biophysics and Molecular Biology·Matthew C Zimmerman, Robin L Davisson
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Lie GaoIrving H Zucker
Feb 9, 2005·Hypertension·Matthew C ZimmermanRobin L Davisson
Feb 26, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John M MakehamPaul M Pilowsky
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Aug 8, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Maram K ReddyKaushik P Patel
Dec 7, 2006·Current Hypertension Reports·Jeffrey R PetersonRobin L Davisson
Apr 30, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Julian F R PatonSergey Kasparov
Feb 21, 2009·American Journal of Hypertension·Elizabeth B Oliveira-SalesRuy R Campos
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Helene GirouardCostantino Iadecola
Sep 1, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Irving H ZuckerLie Gao
Jan 8, 2010·Autonomic Neuroscience : Basic & Clinical·Valdir A Braga

❮ Previous
Next ❯

Citations

Dec 15, 2010·Clinical and Experimental Pharmacology & Physiology·Dmitry N Mayorov
Jan 31, 2012·Clinical and Experimental Pharmacology & Physiology·D D GuimarãesV A Braga
Aug 7, 2014·Current Hypertension Reports·Meghna P MansukhaniVirend K Somers
Feb 10, 2016·Frontiers in Physiology·Clênia de Oliveira CavalcantiCamille de Moura Balarini
Oct 29, 2010·Basic & Clinical Pharmacology & Toxicology·Horacinna M M CavalcanteIsac A Medeiros
Dec 9, 2010·Neuroscience Letters·Marcelo Franchini GiustiEduardo Colombari
Jul 15, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V A BragaD D Guimarães
Mar 10, 2017·American Journal of Physiology. Cell Physiology·Tim D OstrowskiDavid D Kline
Sep 8, 2011·Journal of Veterinary Science·Valdir A Braga
Jul 30, 2014·Perceptual and Motor Skills·Mônica Medeiros RibeiroAntônio Lúcio Teixeira
Nov 28, 2017·The British Journal of Nutrition·Keyth Sulamitta L GuimarãesJosé Luiz de Brito Alves

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Leonardo Máximo CardosoEduardo Colombari
American Journal of Physiology. Heart and Circulatory Physiology
Kevin D MonahanDouglas R Seals
© 2021 Meta ULC. All rights reserved