Superparamagnetic iron oxide: a novel tracer for sentinel lymph node detection in vulvar cancer.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Marcin A JedrykaRafal Matkowski

Abstract

Superparamagnetic techniques for sentinel lymph node (SLNs) biopsy in breast cancer is well recognized but remains novel in the literature in relation to early stage vulvar cancer. The aim of this study was to compare and validate SLN detection using a superparamagnetic iron oxide tracer and a magnetometer probe compared with the standard procedure with a radioisotope (99Tc-technetium 99) and a gamma probe, in patients with vulvar cancer. Patients were included in the study with squamous vulvar tumors less than 4 cm in diameter and without suspicious groin lymph nodes on preoperative magnetic resonance imaging. Patients must have previously qualified for SLN biopsy with a radiotracer as the standard of care. The primary endpoint was the proportion of successful SLN detection with superparamagnetic iron oxide tracer versus 99Tc. The secondary endpoints were average number of SLNs retrieved per patient, proportion of SLNs detected (nodal detection rate), and proportion of pathologically positive results (malignancy rate) per patient and per node comparing both SLN detection methods. A total of 20 patients were included in the study. SLNs were found in all patients with both methods, resulting in similar average distributions (3.1...Continue Reading

References

Apr 15, 2010·Current Topics in Medicinal Chemistry·Debatosh MajumdarDong M Shin
Jul 4, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles F LevenbackCornelia L Trimble
Dec 11, 2013·Annals of Surgical Oncology·Michael DouekUNKNOWN SentiMAG Trialists Group
Feb 4, 2014·The Breast : Official Journal of the European Society of Mastology·Marc ThillNik Hauser
May 29, 2014·British Journal of Cancer·C MeadsS Sundar
Jun 28, 2014·The Cochrane Database of Systematic Reviews·Theresa A LawrieAngela Ralte
Dec 4, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I T RubioM Espinosa-Bravo
May 23, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A Piñero-MadronaUNKNOWN Grupo de Estudios Senológicos de la Sociedad Española de Patologia Mamaria (SESPM)
Apr 26, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Maaike H M OonkAte G J van der Zee
May 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Maaike H M OonkAte G J van der Zee
May 3, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R J NichollsN Haboubi

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Citations

Feb 27, 2021·Frontiers in Oncology·Daphne A J J DriessenJohannes H A M Kaanders
Jun 30, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Thomas WendlerMatthias N van Oosterom
Jul 29, 2021·Current Opinion in Oncology·Giorgia GarganeseAnna Fagotti

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