Superparamagnetic iron oxide particles: what value has the T1 effect in the MR diagnosis of focal liver lesions?

RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
R UrhahnR W Günther

Abstract

To evaluate the T1 effect of superparamagnetic iron oxide (SPIO) in MR imaging of focal hepatic lesions. 21 patients with 34 liver lesions (18 benign) were examined before and immediately after infusion of SPIO particles (Endorem) with a T1-weighted GRE- and SE sequence and a double echo SE sequence at 1.5T. Changes of lesion signal intensity and contrast-to-noise (C/N) ratio were measured in addition to a qualitative analysis of changes in liver vessel signal. In all cases a marked increase of liver vessel signal intensity was observed on T1-weighted images after SPIO infusion. In contrast to malignant lesions, haemangiomas and adenomas showed significant signal changes (p < 0.05) on T1-and T2-weighted images. Highest signal changes were achieved for haemangiomas on T1-GRE images (+80%) followed by T1-SE (+41%) and T2-SE (-42%). Malignant liver lesions exhibited highest C/Ns on T2-weighted postcontrast images. The T1-effect of Endorem offers no benefits in respect of detectability of malignant liver lesions. However, it is helpful in characterising haemangiomas and their differentiation from liver tumours.

Citations

Aug 7, 2008·European Radiology·Priyanka JhaHeike Daldrup-Link

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