Supersaturable Self-Emulsifying Drug Delivery System of Krill Oil with Improved Oral Absorption and Hypotriglyceridemic Function

Journal of Agricultural and Food Chemistry
Yoshiki SetoSatomi Onoue

Abstract

This study aimed to develop a supersaturable self-emulsifying drug delivery system (S-SEDDS) of krill oil (KO), a rich source of docosahexaenoic acid and eicosapentaenoic acid (EPA), to improve its hypotriglyceridemic function. S-SEDDS of KO (KO/S-SEDDS) was prepared by the addition of lysolecithin, glycerin, and hydroxypropyl methylcellulose (HPMC). Self-emulsifying drug delivery system of KO (KO/SEDDS) and KO with HPMC (KO/HPMC) were also prepared for comparison purposes. The physicochemical and pharmacokinetic properties of KO samples were characterized, and the hypotriglyceridemic function of KO/S-SEDDS was evaluated. Micronized droplets in KO/SEDDS and KO/S-SEDDS with a mean diameter of ca. 270 nm could be observed in comparison to KO and KO/HPMC. Both KO/HPMC and KO/S-SEDDS tended to enhance the dissolution behavior of KO, and the S-SEDDS formulation improved the dissolution behavior of KO as a result of micronized droplets and the addition of HPMC. KO/S-SEDDS (60 mg of EPA/kg) improved the oral absorption of KO based on the pharmacokinetic profiling of EPA, and repeated oral administration of KO/S-SEDDS (250 mg of KO kg-1 day-1) for 7 days had a potent hypotriglyceridemic effect on rats with corn-oil-induced hypertriglyc...Continue Reading

References

Jul 1, 1992·Japanese Journal of Pharmacology·K MizuguchiY Saito
Jul 26, 2003·Lipids·Maud CansellNicole Combe
Nov 7, 2003·Journal of Pharmaceutical Sciences·Ping GaoMichael J Hageman
Apr 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R Neslihan Gursoy, Simon Benita
Apr 20, 2004·Drug Development and Industrial Pharmacy·Ping GaoQun Lu
Jul 18, 2006·The American Journal of Clinical Nutrition·Jan L Breslow
Sep 9, 2008·International Journal of Cardiology·Guy D EslickAlan Bensoussan
Sep 19, 2009·Journal of Agricultural and Food Chemistry·Sally TandyJeffrey S Cohn
Jul 22, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Gregory C ShearerPeter Stenvinkel
Apr 14, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Satomi OnoueShizuo Yamada
Aug 28, 2012·European Journal of Nutrition·Natalya Filipchuk VigerustRolf Kristian Berge
Jun 26, 2013·International Journal of Pharmaceutics·Waleed FaisalBrendan T Griffin
Jul 23, 2013·Food Chemistry·Hanna SalminenJochen Weiss
Nov 5, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ahmed AmriChristine Charrueau
Dec 26, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Satomi OnoueShizuo Yamada
Jul 31, 2014·European Journal of Clinical Nutrition·M-P St-OngeB Laferrère
Aug 15, 2014·PloS One·Olga V SavinovaGregory C Shearer
Nov 18, 2014·European Journal of Lipid Science and Technology : EJLST·Peter van Hoogevest, Armin Wendel
Apr 7, 2016·International Journal of Nanomedicine·Dae Ro LeeMyung Joo Kang
Dec 23, 2016·Journal of Agricultural and Food Chemistry·Laura KutznerNils Helge Schebb
Jul 18, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Peter van Hoogevest
Feb 8, 2018·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Gregory C ShearerJohn W Newman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Satomi OnoueShizuo Yamada
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Satomi OnoueShizuo Yamada
© 2022 Meta ULC. All rights reserved