PMID: 9640Sep 1, 1976

Supersaturation in sickle cell hemoglobin solutions

Proceedings of the National Academy of Sciences of the United States of America
J HofrichterWilliam A Eaton

Abstract

The kinetic inhibition of the gelation of hemoglobin S is compared to the change in hemoglobin S soulbility, when the solubility is altered by carbon monoxide, pH, or urea. By means of a new technique, the delay time and the extent of gelation are measured on the same sample. They delay time, td, is found to be proportional to a high power (30-40) of the hemoglobin S solubility. Togehter with the previously reported concentration dependence, this result demonstrates that the rate is proportional to a high power of the supersaturation, S, defined as the ratio of the total hemoglobin S concentration to the equilibrium solubility. The results obey the supersaturation equation td-1 = gammaSn, where gamma is an empirical constant (about 10(-7) sec-1) and n is about 35. The supersaturation equation can successfully account for observations on the kinetics of cell sickling and is therefore used to estimate the increase in the delay time for sickling necessary to produce significant clinical benefit to patients with sickle cell disease.

References

Aug 25, 1975·Journal of Molecular Biology·R W Briehl, J M Salhany
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B Magdoff-FairchildJ F Bertles
Aug 5, 1975·Journal of Molecular Biology·P D RossWilliam A Eaton
May 1, 1975·British Journal of Haematology·A May, E R Huehns
Feb 5, 1976·Journal of Molecular Biology·A P Minton
Mar 22, 1976·Biochemical and Biophysical Research Communications·William A EatonE D Becker
Aug 5, 1974·Biochemical and Biophysical Research Communications·R Malfa, J Steinhardt
Nov 6, 1974·Biochemical and Biophysical Research Communications·K Moffat, Q H Gibson
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D ElbaumT T Herskovits
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J HofrichterWilliam A Eaton
Dec 14, 1972·Journal of Molecular Biology·A Szabo, M Karplus
Nov 5, 1973·Journal of Molecular Biology·R W Briehl, S Ewert
Sep 14, 1971·Journal of Molecular Biology·R M Bookchin, Ronald L Nagel
Jun 1, 1971·The American Journal of the Medical Sciences·R M NalbandianR L Henry
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX

Citations

Jun 21, 1978·Biochimica Et Biophysica Acta·D ElbaumRonald L Nagel
Mar 26, 1980·Biochimica Et Biophysica Acta·T T Herskovits, D Elbaum
Oct 22, 1981·European Journal of Pharmacology·S T OhnishiM Singer
Sep 10, 1982·European Journal of Pharmacology·T Sato, S T Ohnishi
Dec 7, 1984·Biochimica Et Biophysica Acta·R Pennathur-DasB Lubin
Jun 1, 1981·Biophysical Chemistry·R C BenedictB Hedlund
Apr 28, 2004·Biophysical Chemistry·Masato Kodaka
Jan 27, 2004·Journal of Molecular Biology·Oleg Galkin, Peter G Vekilov
Jul 1, 1978·Biophysical Journal·M J Behe, S W Englander
Sep 10, 2002·Journal of Molecular Biology·Gunjan AgarwalR W Briehl
Apr 18, 1998·Biochimica Et Biophysica Acta·Daniel B Kim-ShapiroSamir K Ballas
Aug 6, 1999·Biochimica Et Biophysica Acta·Daniel B Kim-ShapiroSamir K Ballas
Oct 5, 1978·The New England Journal of Medicine·J Dean, A N Schechter
Sep 11, 1997·The New England Journal of Medicine·H Franklin Bunn
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·Constance T NoguchiA N Schechter
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S M Wilson, M W Makinen
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R E BeneschSuzanna Kwong
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J Wyman, S J Gill
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Constance T NoguchiA N Schechter
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H Franklin BunnWilliam A Eaton
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D J AbrahamS E Phillips
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J PeetermansT Tanaka
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W N PoillonA N Schechter
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J J Martin de LlanoJ M Manning
Oct 17, 1983·European Journal of Biochemistry·I M FranklinE R Huehns
May 12, 2010·Annual Review of Biomedical Engineering·Gilda A BarabinoD K Kaul
Nov 1, 1981·The Journal of Clinical Investigation·L R Berkowitz, E P Orringer
Jul 1, 1983·The Journal of Clinical Investigation·D K KaulRonald L Nagel
Jan 1, 1991·The Journal of Clinical Investigation·R M BookchinV L Lew
Jan 15, 1993·Experientia·D K Kaul, Ronald L Nagel
Oct 1, 1999·Journal of Biomedical Optics·M G SowaH H Mantsch
Jan 18, 2016·Current Opinion in Structural Biology·Masatomo SoYuji Goto
Feb 22, 2011·Biophysical Chemistry·Weijun Weng, F A Ferrone
Nov 8, 1989·Journal of Theoretical Biology·C J YuanM E Johnson
Mar 14, 2007·Biophysical Chemistry·Kelly M KneeI Mukerji
Mar 16, 2016·Journal of Molecular Biology·Donna YosmanovichF A Ferrone
Apr 24, 2007·Biophysical Journal·Oleg GalkinPeter G Vekilov
Oct 9, 1979·Journal of Molecular Biology·H R SunshineWilliam A Eaton
May 15, 1979·Journal of Molecular Biology·S J GillJ Wyman
Jun 5, 1979·Journal of Molecular Biology·G W DykesS J Edelstein
Oct 1, 1978·Archives of Biochemistry and Biophysics·P D Ross, S Subramanian
Sep 15, 1977·Journal of Molecular Biology·P D RossWilliam A Eaton
Apr 11, 1977·Biochemical and Biophysical Research Communications·W N Poillon, J F Bertles
Jul 20, 1987·Journal of Molecular Biology·E DanishI M Krieger
Feb 1, 1984·Archives of Biochemistry and Biophysics·E J DelaneyI M Klotz
Jun 25, 1985·Journal of Molecular Biology·F A FerroneWilliam A Eaton
Jun 25, 1980·Journal of Molecular Biology·S J GillJ Wymann
Nov 16, 2004·Biophysical Journal·Garrott W ChristophWilliam A Eaton
Jul 30, 1982·Biochemical and Biophysical Research Communications·H Chang, S M Suzuka
Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S T Ohnishi, M Katsuoka
Jan 18, 2005·Biophysical Journal·Alexey AprelevF A Ferrone
Mar 29, 2016·Nature Structural & Molecular Biology·Troy CellmerWilliam A Eaton
Jan 1, 1989·Annals of the New York Academy of Sciences·R W Briehl
Mar 1, 1993·Baillière's Clinical Haematology·Constance T NoguchiG P Rodgers
Aug 1, 1983·British Journal of Haematology·I M FranklinE R Huehns
Oct 1, 1986·British Journal of Haematology·I M FranklinM A Rosemeyer
Dec 1, 1996·Hematology/oncology Clinics of North America·R M Bookchin, V L Lew
Jan 24, 1977·Biochemical and Biophysical Research Communications·Constance T Noguchi, A N Schechter
Oct 15, 1981·Archives of Biochemistry and Biophysics·D A GabrielC S Johnson
Aug 1, 1978·Archives of Biochemistry and Biophysics·L L Chung, B Magdoff-Fairchild
Apr 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Prajwal CiryamMichele Vendruscolo
Mar 1, 2008·Journal of Molecular Biology·Weijun WengF A Ferrone
Sep 26, 2003·Biophysical Journal·Zhi HuangDaniel B Kim-Shapiro
Aug 17, 2011·Biophysical Journal·Alexey AprelevF A Ferrone
Feb 1, 2015·Trends in Pharmacological Sciences·Prajwal CiryamMichele Vendruscolo
Jan 29, 2002·Journal of Molecular Biology·Jiang Cheng WangR W Briehl
Dec 12, 1978·Biochemistry·Constance T Noguchi, A N Schechter
Apr 8, 2017·Blood·William A Eaton, H Franklin Bunn
Dec 6, 2001·Journal of Molecular Biology·M IvanovaF A Ferrone
Sep 15, 1984·Journal of Molecular Biology·M W Makinen, C W Sigountos
Mar 5, 1979·Journal of Molecular Biology·J Hofrichter
Mar 25, 1979·Journal of Molecular Biology·R C CheethamM A Rosemeyer
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Quan LiWilliam A Eaton
Jul 11, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Ying WangGeorge B Benedek
Apr 11, 2018·Protein Science : a Publication of the Protein Society·F A Ferrone
Sep 21, 1978·Nature·H R SunshineWilliam A Eaton
Dec 14, 1978·Nature·R W Briehl
Nov 11, 1982·Nature·M ColettaWilliam A Eaton
Jan 1, 1989·Hemoglobin·S A Liebhaber
Nov 10, 1995·The Journal of Biological Chemistry·K AdachiS Surrey
May 25, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Zeshan IqbalDaren J Caruana
Jan 1, 1989·Annals of the New York Academy of Sciences·S H Embury
Apr 5, 2018·Clinical Hemorheology and Microcirculation·Daniel B Kim-Shapiro, Mark T Gladwin
Jan 1, 1985·Hemoglobin·J L ConverseJ W Harris
Jul 26, 2002·The Journal of Biological Chemistry·Xiuli XuDaniel B Kim-Shapiro
Jan 1, 1989·Annals of the New York Academy of Sciences·R W Briehl, E S Mann

Related Concepts

Carbon Monoxide
Gel
Hydrogen-Ion Concentration
Thermodynamics
Carmol

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
B Magdoff-FairchildJ F Bertles
Journal of Molecular Biology
P D RossWilliam A Eaton
© 2021 Meta ULC. All rights reserved