Supersonic Shear Wave Ultrasonography for Assessing Tissue Stiffness in Native Kidney

Ultrasound in Medicine & Biology
Daniela RădulescuIonel Alexandru Checheriță

Abstract

Recent years have brought shear wave elastography to the attention of nephrologists as a non-invasive method for detecting kidney fibrosis and, therefore, as a potential tool for reducing the need for kidney biopsy. Few studies are performed on native kidney. We aimed to compare cortical stiffness, assessed by measuring Young's modulus (YM, kPa) with SuperSonic Imaging technology, in patients with various degrees of chronic kidney disease (CKD) compared with healthy individuals. Cortical stiffness was measured by two operators, in different sessions, in 32 patients with CKD stages 3-5 and 20 healthy individuals. Comparison between mean YM values in CKD and those in controls and also between the different stages of CKD was our primary objective. The influence of other possible confounders on YM readings was also investigated and analyzed. Mean YM was significantly greater in CKD patients than in controls. Estimated YM was not able to differentiate the stages of CKD, except stage 5. Intra-subject variability was greater in CKD than in controls. Body mass index was the most important confounder in multiple analyses, in both the CKD and control groups. Our results highlight a positive correlation between increased cortical stiffnes...Continue Reading

Citations

Dec 19, 2020·Clinical Hemorheology and Microcirculation·Qin Liu, Zhengrong Wang
Aug 29, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Minyan ZhuShan Mou

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